Okayama University Research: Inorganic Biomaterials for Soft-Tissue Adhesion

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Researchers at Okayama University describe in May 2017 edition of Acta Biomaterialia a new type of biocompatible adhesive material. The adhesive, made from nanoparticles of hydroxyapatite, glues both synthetic hydrogels and mouse soft tissue, providing a promising alternative to organic materials currently in use for clinical applications.

Dispersions containing hydroxyapatite (HAp) nanoparticles, dried and made into plates have outstanding adhesive properties, and are biocompatible and biodegradable.

Results will help not only in developing an efficient approach to close incised soft tissues, but also in finding novel ways to integrate soft tissues with synthetic hydrogels (such as drug reservoirs).

Researchers at Okayama University describe in May 2017 edition of Acta Biomaterialia a new type of biocompatible adhesive material. The adhesive, made from nanoparticles of hydroxyapatite, glues both synthetic hydrogels and mouse soft tissue, providing a promising alternative to organic materials currently in use for clinical applications.

As an alternative to surgical stitching with suture, the practice of using adhesive organic materials for joining soft tissue has been around for decades. However, the currently used clinical adhesives often suffer from limited biocompatibility and/or sub-optimal adhesive strength. A team of researchers led by Takuya Matsumoto from Okayama University and colleagues has now identified a class of biocompatible–biodegradable compounds showing promising adhesion properties when applied to mouse soft tissues.

The scientists relied on the recent discovery that certain nanostructured materials display remarkable adhesiveness. For example, introducing a dispersion of silicon oxide nanoparticles between two hydrogels results in rapid adhesion of the hydrogels — an effect now developed further for industrial, non-clinical applications. In order to achieve the level of biocompatibility required for clinical usage, Matsumoto and colleagues experimented with nanoparticles of hydroxyapatite (HAp), an inorganic material found in human hard tissues such as bones and teeth. HAp-composites are routinely used for orthopedic and dental implants, as well as in tissue engineering. The researchers reckoned that dispersions of nanoparticulate HAp should behave as biocompatible adhesives — an idea they were able to confirm experimentally.

Matsumoto and colleagues first examined the effect of HAp-nanoparticle dispersions on the adhesion of synthetic hydrogels; the presence of HAp clearly enhanced the level of adhesion. Drying the dispersions — resulting in solid HAp ‘plates’ — increased the cohesion between the HAp nanoparticles, and using the plates as the adhesive agent then led to even better inter-hydrogel adhesion. The scientists then tested the HAp plates on different mouse soft tissues: muscle, lung, kidney and other tissues could be successfully glued together. An adhesion strength at least twice as large as obtained with a commercial organic glue was observed for mouse skin tissues.

The findings of Matsumoto and colleagues are not only relevant for developing new procedures for surgical-wound healing, but also for drug-delivery technologies — the potential of hydrogels as drug containers has long been recognized. In the words of the researchers: “our results will help not only in developing an efficient approach to close incised soft tissues, but also in finding novel ways to integrate soft tissues with synthetic hydrogels (such as drug reservoirs).”

Background
Hydroxyapatite
Hydroxyapatite (HAp), also known as hydroxylapatite, is a calcium-containing mineral occurring in human bones and teeth. Synthetic HAp is often used as a coating for prostethic implants, such as hip, bone or teeth replacements, as it is believed to stimulate osseointegration. The experiments of Takuya Matsumato from Okayama University and colleagues have now demonstrated the potential of dispersions of HAp nanoparticles as biocompatible, inorganic adhesive materials.

Hydrogels
A hydrogel is a material consisting of a three-dimensional network of hydrophylic (i.e. not water-repellent) polymeric chains with water molecules in between. Hydrogels can contain up to 90% water, and are used in various biotechnological and medical applications. They are also used to test the adhesive properties of biomaterials and drug-delivery systems, as in the study of Matsumato and colleagues: tests of the adhesiveness of HAp nanoparticle dispersions led to the identification of a promising biocompatible adhesive capable of gluing mouse soft tissues together.

Reference
Masahiro Okada, Akira Nakai, Emilio Satoshi Hara, Tetsushi Taguchi, Takayoshi Nakano & Takuya Matsumoto. Biocompatible nanostructured solid adhesives for biological soft tissues. Acta Biomaterialia, 5 May, 2017.
DOI: doi: 10.1016/j.actbio.2017.05.014.

Further information
Okayama University
Website: http://www.okayama-u.ac.jp/index_e.html
Okayama Univ. e-Bulletin: http://www.okayama-u.ac.jp/user/kouhou/ebulletin/

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Hiromi Tokiwa
Okayama University
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