The class of small molecule phenylalanine derivatives impede Growth Factor Receptor-Bound Protein 2 activity and hinder cancer cell migration, invasion and angiogenesis.
BOSTON (PRWEB) January 31, 2018
One Million Solutions in Health announces an opportunity to license science from the NIH which offers potential payloads for cancer- targeted delivery systems.
One Million Solutions in Health has partnered with the United States' National Institutes of Health Office of Technology Transfer (NIH-OTT) and the National Cancer Institute Technology Transfer Center (NCI-TTC) and is seeking to spread awareness of NIH technologies and advances.
In this One Million Solutions in Health webinar entitled “NIH Licensing Opportunity: A Class of Small Molecule Phenylalanine Derivatives as Potential Payloads for Cancer-Targeted Delivery Systems" end users are provided with the opportunity to acquire knowledge about the latest science and technology directly from NIH scientists themselves. Users can also take part in One Million Solutions in Health's exclusive Signature Square process where they are able to assess the innovation, make inquiries and give open feedback to the scientists.
This class of small molecule phenylalanine derivatives impede Growth Factor Receptor-Bound Protein 2 activity and hinder cancer cell migration, invasion and angiogenesis.
The adaptor protein growth factor receptor-bound-2 (Grb2) serves as a key motioning arbitrator of numerous growth factor receptors and intracellular tyrosine kinases that advance cell motility, propagation and morphogenesis.
The act of motioning or signalling is established through a selective, high affinity binding interaction between the Grb2 Src homology type-2 (SH2) domain and specific phosphotyrosyl-containing motifs in activated tyrosine kinases, and permits the creation of multi-molecular signalling complexes that connect kinases to crucial downstream monitoring networks.
By taking advantage of the unique structural features of this relationship, small synthetic peptidomimetic Grb2 SH2 domain adversaries were realistically designed and advanced that bind tightly and selectively to the Grb2 SH2 domain; therefore, the interaction with activated tyrosine kinases can be impeded. These competitive binding adversaries strongly hinder growth factor stimulated cell motility, matrix invasion, and branching morphogenesis in model cultured cell systems. With IC50 values of 30 nM or less, they block angiogenesis in the avian CAM assay, and block tumour metastasis in animal models.
Ultimately, these Grb2 SH2 domain antagonists may possess the power to serve as a payload for cancer-targeted therapeutic delivery systems.
If you would like to license unique solutions to combat cancer cell migration, invasion and angiogenesis, then this presentation is for you.
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ABOUT THE TECHNOLOGY EVALUATION CONSORTIUM
The Technology Evaluation Consortium™ from One Million Solutions in Health™ is dedicated to improving and accelerating life sciences R&D and health care outcomes. The Technology Evaluation Consortium brings together life sciences and/or health care companies and industry vendors or scientists, and other relevant partners (e.g., government and Universities), to evaluate and validate technologies or services in a collaborative environment.
The model empowers technology providers and scientists, and industry end-users, to collectively assess a number of solutions in a cost-effective manner, producing a depth and breadth of results that no company can achieve alone. Our mission is to triage and streamline new technology consideration for the industry, and to be the place for the industry to conduct their evaluations and validations.
Dawn Van Dam
Executive Director and CEO