This presentation highlights how in situ particle characterization is used by Johnson & Johnson to control batch to batch repeatability and identify batch endpoints while correlating to consistent downstream dissolution properties.
Columbia, MD (PRWEB) September 21, 2010
During the Fluid Bed with Inline Particle Characterization: A Predictor of Dissolution Quality online seminar on October 27, Steve Mehrman of Johnson & Johnson will discuss the use of inline FBRM® technology to provide critical insight in to fluid bed operations. In the pharmaceutical industry, this data has been linked/modeled to downstream product Critical Quality Attributes (CQAs) leading to real-time feedback during granulation.
During the development of quality solid dosage forms, fluid bed granulation is often employed due to its adaptable processing capabilities with respect to different Active Pharmaceutical Ingredients (APIs), formulations and in-house experience. Characterization of particle size distributions is critical to build process understanding and an overall control strategy for solid dosage development.
"This presentation highlights how in situ particle characterization is used by Johnson & Johnson to control batch to batch repeatability and identify batch endpoints while correlating to consistent downstream dissolution properties", says Benjamin Smith, Market Manager – Particle System Characterization. "The Fluid Bed with Inline Particle Characterization: A Predictor of Dissolution Quality presentation provides attendees with knowledge they can immediately use."
METTLER TOLEDO FBRM® C35 tracks the rate and degree of change to particles and particle structures as they naturally exist in process. This enables formulation scientists and engineers to quickly correlate particle system dynamics with downstream product quality and processing efficiency. This allows for faster understanding and optimization of a granulation with no sampling required. FBRM® C35 is also the winner of the Powtech/TechnoPharm Innovation Award 2010.
METTLER TOLEDO provides the enabling technology, software and people that can help build a seamless workflow to translate bench scale chemistry into a commercial process. For more than 20 years, our enabling tools and services have been a strategic resource providing critical information for thousands of development scientists and engineers. Companies have used that knowledge to accelerate the discovery, development and scale-up of new chemical processes spanning the chemical and biopharmaceutical industries.