Scientific Publication on GenoTrim Explains Gene Link to "Sweet Tooth" as a Cause of Weight Problems
Researchers from Salugen, Inc. Wake Forest University and Chang Jung University in Taiwan describe the genetic basis of how the "sweet tooth" sugar craving contributes to weight gain.
San Diego, Calif. (PRWEB) June 13, 2007 -- Salugen, Inc. (www.salugen.com), a leading personalized health and wellness company, announces a scientific publication explaining how a genetic "sweet tooth" can contribute to weight management challenges. In a publication entitled, "Genotrim™, a DNA-customized nutrigenomics product, targets genetic factors of obesity: Hypothesizing a dopamine-glucose correlation demonstrating reward deficiency syndrome (RDS)," in Medical Hypotheses, researchers from Wake Forest University School of Medicine and other leading institutions explain a link between the "pleasure" molecule dopamine and glucose to describe the weight loss effects of GenoTrim (www.GenoTrim.com).
In this publication, scientists further explain the role of unwanted weight and Reward Deficiency Syndrome (RDS). RDS results from a dysfunction in the Brain Reward Cascade, which directly links abnormal craving behavior with a defect in the dopamine D2 receptor gene and other genes. Dopamine is a powerful neurotransmitter in the brain that controls feelings of well being.
Dr. Kenneth Blum, Professor in Department of Physiology & Pharmacology at Wake Forest University School of Medicine and Chief Scientific Officer for Salugen, Inc., states that "the genes involved in RDS provide a targeted blueprint for potential weight treatment." Dr. Blum goes onto say, "Reward Deficiency Syndrome involves a form of sensory deprivation of the brain's reward or pleasure mechanisms. RDS can be manifested in relatively mild or severe forms and causes the inability to derive reward from ordinary, everyday activities. We believe that we have discovered at least one genetic variation that leads to an alteration in the reward pathways of the brain. It is a variant form of the gene for the dopamine D2 receptor, called the A1 allele. This genetic variant also is associated with a spectrum of impulsive, compulsive, and addictive behaviors. The concept of Reward Deficiency Syndrome unites those disorders and may explain how simple genetic anomalies give rise to complex aberrant behavior."
In this scientific publication, researchers explain that glucose or sugar intake effects dopamine release. Dr. Blum further explains, "The direct effect of dopamine on glucose release has been studied and dopamine is known to induce hyperglycemia in both animals and man. We suggest that increasing glucose release from tissue would reduce cravings for glucose and carbohydrates."
Also in this scientific publication, the authors explain some similarities between the mechanism of prescription weight loss medicine, Meridia (sibutramine HCl), and DNA-customized dietary supplement, GenoTrim. Dr. Blum states, "In its simplest form, a component of GenoTrim mirrors Meridia's mechanism and should produce similar anti-craving effects. However, the hypothesis is that DNA-customized GenoTrim, unlike sibutramine HCl, works by answering certain nutrient needs required to silence excessive cravings originating from those systems and delivers the nutrient amounts based upon genetic predisposition."
Dr. Blum continues, "By understanding these biological and genetic factors influencing weight, we propose that a DNA-customized nutritional regimen, like GenoTrim, may be a critical component to reducing unwanted weight." One of the genes measured in the GenoTrim genetic analysis is the Sweet Tooth Gene™ or the Dopamine D2 Receptor Taq1 allele.
About GenoTrim
GenoTrim is a DNA-customized nutritional solution for weight management. Based upon an analysis of five important genes effecting weight, GenoTrim ingredients and dosages are genetically-guided to address the underlying genetic factors involved in hormones and metabolism that Harvard Medical Experts suggest influence 70% to 80% of overweight cases. By addressing genetic factors that make individuals prone to weight problems, GenoTrim has demonstrated in studies to help reduce weight, appetite, sugar cravings, snacking, and late-night eating, as well as help support improved sleep, mood, and energy levels which results in sustainable weight loss. GenoTrim will be available in the United States through DNA Services of America (www.dnasoa.com) later in 2007. For more information on GenoTrim, please visit www.genotrim.com.
About Salugen™
Salugen, Inc., a leading personalized health and wellness company, engages in the discovery, development and commercialization of patent-protected genetic tests and companion DNA-customized therapeutics worldwide. With over 30 years of research conducted on the genetic causes and pharmacology of many healthcare concerns, Salugen is a pioneer and leader in delivering personalized medicine. Currently, the Company commercializes nutrigenomic technologies where genetic analysis guides the formulation and delivery of nutritional solutions that are customized to the individual. The company has headquarters in San Diego, CA, with its high-complexity CLIA-certified laboratory services in Los Angeles, CA. For additional information about the company, please visit http://www.salugen.com.
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