Nanomedical Diagnostics Benchtop Kinetic Binding Platform Displays Unprecedented High Signal-to-Noise Ratio in Comparison Study Showcased in MRS Advances

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Label-free Agile R100 demonstrates detection of Zika antigen at 10 times lower concentration than Octet.

Agile R100 Label-Free Graphene Biosensor for Kinetic Binding Data

Agile R100 Label-Free Kinetic Binding Assay

Agile R100 is a benchtop label-free assay that cuts out numerous steps typical of an ELISA, and provides kinetic binding data in agreement with the Octet at a fraction of the cost.

Nanomedical Diagnostics, a life science company pioneering label-free graphene biosensors for use in drug discovery, today announced that the paper, “Towards Novel Graphene-Enabled Diagnostic Assays with Improved Signal-to-Noise Ratio,” which features Agile R100’s significant increase in signal-to-noise ratio over Bio-Layer Interferometry (BLI) and ELISA platforms, has been published in MRS Advances, a journal that highlights new and emerging science. The paper compares Zika antigen detection on an Agile R100 versus an Octet RED96, a BLI platform. It also compares measurement of an inflammatory protein, IL-6, with an Agile R100 versus with an Invitrogen ELISA kit.

While BLI and ELISA are widely used in drug discovery and disease diagnostics, the platforms suffer noise interference at ultra-low concentrations, which reduces measurement sensitivity. Highly-sensitive measurements are necessary to develop biopharmaceuticals at therapeutically-relevant levels and to gain accurate early clinical results. In this study, Agile R100 exhibited detection of Zika viral antigen at a concentration 10 times lower than on the Octet RED96, a standard kinetic binding drug discovery platform. Similarly, Agile R100 lowered the limit of detection for inflammatory protein IL-6 by 10 times, versus on an ELISA, a conventional tool for clinical diagnostics.

“This study has broad-ranging healthcare implications,” says Nanomedical Diagnostics CEO, Ross Bundy. “The Octet is an expensive machine that is costly to run, plus requires extensive training. ELISAs are time-consuming and technically onerous. Agile R100 is a benchtop label-free assay that cuts out numerous steps typical of an ELISA, and provides kinetic binding data in agreement with the Octet at a fraction of the cost. Researchers now have access to an intuitive, highly-sensitive, quantitative platform to accelerate drug development and disease research.”

Agile R100, an easy-to-use benchtop kinetic binding assay built with cutting-edge proprietary Field Effect Biosensing (FEB) technology, employs an electrical form of measurement rather than optical methodologies as BLI and ELISA utilize. The 10x increase in signal-to-noise of Agile R100 over conventional optical methods represents a significant advancement in drug development and highlights the potential for future clinical capabilities.

About Nanomedical Diagnostics

Nanomedical Diagnostics (“Nanomed”) is a life science company based in San Diego, CA. Nanomed has developed a breakthrough electrical assay based on proprietary Field Effect Biosensing (FEB) technology that provides real-time label-free kinetic binding and affinity data. Unique graphene biosensors at the heart of the assay deliver highly-sensitive kinetic characterization of small molecules in complex media such as DMSO, using unprecedentedly small amounts of sample, making the platform a novel orthogonal technique for drug discovery hit validation and lead optimization.

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Angela Shue
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