"Close monitoring and an individualized risk- vs-benefit assessment is really a good thing, as well as an emphasis on continued lifestyle changes." Annie Culver, Mayo Clinic
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Rancho Palos Verdes, CA (PRWEB) January 12, 2012
For the past year studies have shown an increased risk of developing diabetes for people taking statin therapy. Data published in June of 2011 from studies including PROVE-IT, A to Z, TNT, IDEAL and SEARCH all showed significant increased risk of diabetes associated with statin use. The data was published by Dr Kausik Ray (St George's University of London, UK).
The current review of the WHI data lead by senior investigator Dr Yunsheng Ma (University of Massachusetts Medical School, Boston) indicated the risk of developing diabetes for women aged 50-79 was 48%. "The association between diabetes risk and statin therapy was not observed with any one type of statin, and it seems to be a class effect," said Ma.
Annie Culver (Mayo Clinic, Rochester, MN) reported in the Archives of Internal Medicine, said that "close monitoring and an individualized risk- vs-benefit assessment is really a good thing, as well as an emphasis on continued lifestyle changes."
Dr Kirsten Johansen (University of California, San Francisco), editor of the Archives, noted that the increased risk of diabetes in women without CVD has "important implications for the balance of risk and benefit of statins in the setting of primary prevention, in which previous meta-analyses show no benefit on all-cause mortality."
The JUPITER trial looked at patients with normal LDL levels but elevated C-reactive protein (>2.0 mg/lL) and found significant increases in risk of developing diabetes among women with and without CVD. The increased risks were 46% and 48% respectively. C-reactive protein is biomarker that measures chronic inflammation and has been tied to increased CVD risks along with a host of other ailments.
Omega-3 fatty acids, vitamin D, turmeric and cocoa are all clinically proven to reduce chronic inflammation and CVD risk. People who are pre-diabetic might consider natural supplementation and lifestyle modification prior to starting statin therapy.
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By James Lowenstein