Beyond Turbidity: Selecting Appropriate Technology for in Situ Monitoring and Control of Complex Particle and Droplet Systems

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METTLER TOLEDO recently released the technical review, Advancing Beyond Turbidity: Selecting Appropriate Technology for In Situ Monitoring and Control of Complex Particle and Droplet Systems, which discusses how to characterize particle and droplet size, shape, and count while measuring in situ and in real time.

Complex Particle and Droplet Systems

When is turbidity not enough? For particle and droplet systems, where particle size, shape and concentration are changing simultaneously, there are significant advantages to using more advanced inline technology to fully understand and control how the particle system evolves over time.

The Advancing Beyond Turbidity: Selecting Appropriate Technology for In Situ Monitoring and Control of Complex Particle and Droplet Systems Technical Review discusses how to characterize particle and droplet size, shape, and count while measuring in situ and in real time. The article focuses on various applications including crystallization (grow bigger crystals), suspension flocculation (improve solid-liquid separation and filtration), emulsions (ensure droplet distribution stability) and fermentation processes (track cell count and dimension for batch repeatability).

METTLER TOLEDO FBRM® (Focused Beam Reflectance Measurement) and METTLER TOLEDO PVM® (Particle Video Microscopy) are tools which provide the ability to measure particle dimension, shape, and number while measuring inline with no sampling necessary. In situ particle measurement tools allow scientists and engineers to optimize, troubleshoot, and control process performance in the laboratory or manufacturing environment.

Download the Advancing Beyond Turbidity: Selecting Appropriate Technology for In Situ Monitoring and Control of Complex Particle and Droplet SystemsTechnical Review.

METTLER TOLEDO provides the enabling technology, software and people that can help build a seamless workflow to translate bench scale chemistry into a commercial process. For more than 20 years, our enabling tools and services have been a strategic resource providing critical information for thousands of development scientists and engineers. Companies have used that knowledge to accelerate the discovery, development and scale-up of new chemical processes spanning the chemical and biopharmaceutical industries. After purchasing Lasentec® in 2001, METTLER TOLEDO has become the world leader for inline particle/droplet size, shape, and count characterization.

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Patricia Hicks
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