Res-JÜVENTA Responds to Research about Resveratrol’s Potential Effects in Sensitizing Leukemia and other Cancer Cells

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Res-JÜVENTA Responds to Research about Resveratrol’s Potential Effects in Sensitizing Leukemia and other Cancer Cells

Recent and repeated publications on research suggest that resveratrol may be effective in aiding to sensitize certain types of leukemias.1 It has been observed that tumors develop resistance to chemotherapeutic agents and hence their effectiveness starts decreasing. The drug resistance in cancer patients is partially due to the high endogenous levels of heat shock protein. Resveratrol helps in lowering levels of heat shock protein and thereby may prevent drug resistance and stimulate chemo-sensitization.2 Also, researchers say this antioxidant found in grape skins appears to work by targeting the cancer cell's energy source from within and crippling it. When combined with radiation, treatment with resveratrol prior to radiation also induced cell death, an important goal of cancer treatment.3 Overall, the combination may lead to better treatment.

The cancer research community is always in search for effective chemo-sensitizers which sensitize tumors to the chemotherapeutics. According to studies, resveratrol can sensitize a number of cancer cells, including chronic lymphocytic leukemia, to the anti-tumor effects of some conventional chemotherapeutic drugs. The action of resveratrol is due to its apoptotic quality to aide inducing death of the tumor cells without affecting adjacent healthy cells. Resveratol caused internucleosomal DNA fragmentation, suggesting apoptosis as the mode of cell death in 32Dp210 mouse myeloid leukemia cells.4 Taken together, the data, showing that resveratrol is an effective in vitro inhibitor of fresh acute myeloid leukemia (AML) cells, suggest that this compound may have a role in future therapies for AML.5.

Resveratrol (trans-3,4',5-trihydroxystilbene), a compound found largely in the skin of red grapes, came to scientific attention during the mid-1990s as a possible explanation of the “French Paradox”- which is- low incidence of heart disease among the French people who eat relatively high fat diet. Resveratrol has been reported to exhibit cardioprotective and chemopreventive activity against chemical carcinogenesis. It has also been shown to have growth inhibitory activity toward solid tumors in vivo. The antiproliferative effect of resveratrol on these leukemia cells is irreversible, because cells do not resume growth after the removal of resveratrol from the cultures.4 Over the last two decades, research has been on going to find out more about the potent health benefits of this anti-oxidant.

Dietary constituents of food have been shown to provide protection against many diseases and reduce the severity of others. For instance, moderate consumption of red wine has been associated with reduced mortality from coronary heart disease and breast cancer. The beneficial effects of red wine against these diseases have been attributed to resveratrol, a polyphenolic compound present in red wine (with the highest concentration in traditional Spanish red wine). In the plant kingdom, especially in grapes, resveratrol is believed to provide protection against environmental stress and plant pathogens and it functions as a phytoalexin which protects against fungal infections. Numerous biological effects of resveratol, including anti-inflammatory, antiproliferative and chemopreventive activities have been described.4

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According to researcher, Paul Okunieff, MD chief of radiation oncology at the University of Rochester Medical Centre, “Red wine consumption during chemotherapy or radiation treatment has not been well studied, but research is still going on to find its exact concentration and its action within the cell. But the important part is resveratrol seems to have a therapeutic gain by making tumor cells more sensitive to radiation and making healthy tissues less sensitive. While additional studies are needed, this research indicates that resveratrol has a promising future as part of the treatment for cancer".3

When tested on untreated cancer cells extracted from patients newly diagnosed with the most common form of leukemia in adults (chronic lymphocytic leukemia), resveratrol killed the cancer cells with no adverse effects on normal healthy cells. Resveratrol also increased the effectiveness of two conventional leukemia drugs (fludarabine and cladribine).6

Res-JÜVENTA, a proven dietary supplement contains uniquely vitis vinifera resveratrol, 100% naturally harvested from the Spanish Blue Grape. Urs Fischer, CEO of Yahüurs LLC, US distributor of Res-JÜVENTA: “Due to Res-JÜVENTA’s nature of a dietary supplement, we point out that the research and any statements mentioned in this article have not been individually evaluated by the Food and Drug Administration and Res-JÜVENTA, is not intended to diagnose, treat, cure or prevent any disease. Nevertheless, we are obviously excited about the prospect of additional research on resveratrol’s potential ability to complement traditional approaches to address leukemia and other forms of cancers.”

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Urs Fischer

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