Beaumont Launches 1st U.S. Adult Human Stem Cell Study for Stress Urinary Incontinence

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Stem cells harvested from the patient's leg are used to strengthen weak muscles that can lead to urinary leakage.

Urology Chairman Kenneth Peters, M.D., Beaumont Hospital, Royal Oak, Mich., is leading the nation's first research study using a person's own stem cells to treat stress urinary incontinence.

If successful, (autologous) muscle-derived stem cell therapy could offer new hope to people with stress urinary incontinence and offer them a life free of urinary leakage

Urologists at Beaumont Hospital (http://www.beaumonthospitals.com ) are first in the United States to treat stress urinary incontinence using a person's own stem cells through a research study. The stem cells are used to strengthen weak muscles that control urination.

"If successful, (autologous) muscle-derived stem cell therapy could offer new hope to people with stress urinary incontinence and offer them a life free of urinary leakage," says Urology department Chairman Kenneth Peters, M.D., who is leading the research at Beaumont.

Stress urinary incontinence - the cause of leakage with coughing or physical activity - affects about 13 million Americans, most of them women, but also men who have had a prostatectomy (surgery for prostate cancer).

Current treatments, including medicine, exercises and surgery, are not always effective and may have undesirable side effects.

The stem cells from 48 female research participants age 18 or older will be collected at Beaumont Hospital, Royal Oak, and duplicated. The cells will then be injected into the muscles that control urination to strengthen them and prevent leakage.

Participation will last 12-14 months, and will include physical exams, procedures to assess the bladder, completing voiding diaries and questionnaires and a variety of diagnostic tests. A small sample of the participant's thigh muscle will be collected, which is the source of the stem cells. Pregnant or nursing women may not participate.

There is no charge for study-related tests and procedures. Participants will be reimbursed up to $385 for travel to and from the hospital.

Call Debbie Hasenau, R.N., Urology research, at 248-551-3355 for more information.

Beaumont urologists offer endoscopic, robotic and minimally invasive laparoscopic surgical options as well as traditional surgeries, in addition to treatment, for kidney stones; painful bladder conditions including over-active bladder; incontinence; sexual dysfunction; urologic cancer; prostate conditions; male infertility; voiding dysfunction; and erectile dysfunction. Doctors at Beaumont are pioneering a revolutionary nerve rerouting surgery to help adults with spinal cord injuries or children with spina bifida gain bladder control and are first in the United States to research using a person's own stem cells to treat stress urinary incontinence. Beaumont's Urology program is ranked 31st out of 50 on U.S. News & World Report's "America's Best Hospitals" list. Visit Beaumont on the Web at http://www.beaumonthospitals.com.

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Colette Stimmell
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