Advancement in Biologic Protein Expression Webinar Hosted by Selexis SA

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Selexis CSO Demonstrates How the Selexis SURE CHO-Mplus™ Library Can Improve Product Yield in Mammalian Cell Lines

The CHO-Mplus™ Library addresses secretion bottlenecks

The CHO-Mplus™ Library addresses secretion bottlenecks

Entitled “The Selexis SURE CHO-Mplus™ Library - A Novel and Powerful Advancement in Biologic Protein Expression,” the 60 minute webinar will begin at 4:00 PM CEST | 10:00 AM EDT | 7:00 AM PDT on Wednesday, June 19, 2013.

Selexis SA, a serial innovation company focused on drug discovery for lead identification and cell line development for scale-up and manufacturing of therapeutic protein drugs, announced today it will host a free webinar to educate scientists and researchers about the newly launched SURE CHO-Mplus™ Library to address a broad range of protein production bottlenecks, including metabolic limitations, trafficking backlogs, improper folding and altered post-translational modifications to boost the overall expression of therapeutic protein drugs.

Entitled “The Selexis SURE CHO-Mplus™ Library - A Novel and Powerful Advancement in Biologic Protein Expression,” the 60 minute webinar will begin at 4:00 PM CEST | 10:00 AM EDT | 7:00 AM PDT on Wednesday, June 19, 2013.

Registration URL: https://attendee.gotowebinar.com/register/1073373288445877504
Webinar ID: 123-386-987

In this webinar you will learn:

  •     An overview of the SURE CHO-M production cell line
  •     The construction of the SURE CHO-Mplus™ combinatorial library
  •     How to implement the SURE CHO-Mplus™ Library platform to efficiently advance drug discovery and protein production programs
  •     Case studies utilizing the SURE CHO-Mplus™ Library

Who should attend?

  •     Any scientist working with recombinant protein either as a target or as a future drug
  •     Cell line development scientists and researchers
  •     Biologics development scientists
  •     Cellular biochemists

When:
Wednesday, June 19, 2013
4:00 PM CEST | 10:00 AM EDT | 7:00 AM PDT
50 minute presentation
10 minute Q/A

Webinar Abstract:
The Selexis SURE CHO-Mplus™ Library - A Novel and Powerful Advancement in Biologic Protein Expression

With certain recombinant proteins, optimal expression cannot be achieved by elevated transcription alone. Low productivity can be the result of a myriad of issues including faulty cleavage and protein precipitation, improper folding, metabolic overload, or backlog in protein translocation or vesicle trafficking. Within Selexis’ SURE CHO-Mplus™ Library a variety of cellular pathway components have been modified to address specific bottlenecks, such as aberrant glycosylation, improper protein folding, metabolic or translation issues. The SURE CHO-Mplus™ Library has been shown to significantly improve production levels of a broad range of proteins including difficult-to-express monoclonal antibodies, enzymes, structural proteins and fusion proteins such as Fc-fusions and minibodies.

About the Speaker:
Pierre-Alain Girod, PhD, Chief Scientific Officer
Dr. Girod joined Selexis in 2006 and was promoted to Chief Scientific Officer in 2007. Dr. Girod studied and received his PhD from the University of Lausanne. Prior to joining Selexis, Dr. Girod worked at the Department of Biology at the University of Lausanne in the field of targeted protein degradation. Earlier in his career, Dr. Girod completed a postdoctoral fellowship at the University of Wisconsin-Madison in the degradation of proteins by the ubiquitin pathway. In 1993 he returned to Switzerland where he discovered a family of genetic sequences involved in the epigenetic regulation of genes. This discovery has subsequently been used to by pharmaceutical and biotechnology companies to boost expression of therapeutic proteins.
Where:
Registration URL: https://attendee.gotowebinar.com/register/1073373288445877504
Webinar ID: 123-386-987

About Selexis SA
Headquartered in Geneva, Switzerland, Selexis SA is a global life science company with innovative technologies and world-class expert services for drug discovery, cell line development and scale-up to manufacturing of therapeutic proteins. The Company’s SUREtechnology Platform™ is based on Selexis Genetic Elements™ — novel DNA-based elements that control the dynamic organization of chromatin within all mammalian cells and allow for higher and more stable expression of recombinant proteins. Selexis has generated over 1,700 cell lines being used in a variety of programs from drug discovery to late-stage clinical trials.
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Robert Meister
Selexis SA
(602) 953-1716
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