Special Encapsulation Methods Must Be Employed To Preserve Resveratrol In Dietary Supplements

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Contrary to other published reports, resveratrol dietary supplements are biologically available following oral consumption. But light, heat and oxygen can alter resveratrol into a less active form. Only Longevinex capsules preserve resveratrol in an opaque, airtight capsule (Licaps, Capsugel).

Red wine molecules hold great promise to improve health and longevity, but if this natural molecule is to live up to its billing it must be specially preserved to prevent rearrangement into less active forms

Scientific studies confirm that red wine/resveratrol pills are orally absorbed and bioavailable for up to nine hours in the human body, but must be specially fabricated to protect from a degradation process called isomerization that alters the resveratrol molecule into a far less active form, says Bill Sardi, President of Longevinex™.

One of the nagging obstacles for resveratrol as a dietary supplement has been its seeming lack of oral bioavailability. At least four times in 2004 news reports claimed red wine pills are useless.

While studies show that better than 70 percent of oral resveratrol is absorbed (Drug Metabolism 32: 1377-82, 2004), once metabolized in the liver researchers mistakenly believed it could not be used by human tissues. In fact, liver metabolism (a process called glucuronidation) preserves resveratrol in the human body for up to 9 hours. An enzyme called glucuronidase, which is produced abundantly at sites of inflammation and infection, frees resveratrol to be delivered at the right time and place, says Sardi. Some novel drug delivery systems are based upon this liver metabolism, adds Sardi. (J Pharmacology Experimental Therapy 302:369-73, 2002; Drug Metabolism Disposition 32: 1377-82, 2004) One report says that liver metabolism actually "prolongs the effectiveness of resveratrol in humans." (J Pharm Science 93:2448–2457, 2004)

"Red wine molecules hold great promise to improve health and longevity, but if this natural molecule is to live up to its billing it must be specially preserved to prevent rearrangement into less active forms," says Sardi.

Scientific studies reveal that exposure to ultraviolet light, heat and oxygen can alter resveratrol from its active (trans) form to its far less active (cis) form in dietary supplements unless special measures are employed to protect these molecules. (Journal Agriculture Food Chemistry 44: 1253-57, 1996; J Chromatography B Biomed Sci Applications 21;702:103-10, 1997) In one experiment, the photo conversion of 100% trans to cis resveratrol was rapid, about 8 percent per minute at room temperature when exposed to ultraviolet radiation, and after 10-15 minutes of exposure time cis resveratrol was greater than trans resveratrol. (Electrophoresis 22: 2574-79, 2001)

Longevinex® is the only red wine/resveratrol dietary supplement produced in a similar fashion to research-grade resveratrol. Laboratory researchers commonly use trans resveratrol that is sealed in an opaque glass vial and refrigerated. Similarly, the ingredients in Longevinex® capsules are processed in a nitrogen (non-oxygen) environment and protected from light exposure by placement in an opaque capsule, then sealed in a foil package. The liquid ingredients are sealed inside the capsule in an airtight manner using Licaps® technology (Capsugel®).

Longevinex™ capsules have been shown to retain trans resveratrol for up to 12 months following date of manufacture. The unique ingredients in Longevinex™ capsules (resveratrol, quercetin, rice bran, lecithin) are designed to further stabilize its contents and enhance absorption and penetration into remote tissues in the body. (Patent Applied For)

Red wine molecules have made headlines in the past two years for their ability to activate a gene in animals akin to the human Sirtuin 1 gene. The Sirtuin 1 gene is known to control the rate of aging of living organisms by virtue of its ability to produce DNA repair enzymes and mimic the beneficial effects of calorie restriction. Only the trans form of resveratrol is known to activate the Sirtuin 1 gene. (Nature 425: 191-96, 2003)

For more information, please visit http://www.longevinex.com.

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