Newly Published Study Finds Important Association Between Oxidative Stress, Microvascular Aging and Healing

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A newly published study, investigating the proper blood vessel formation (angiogenesis), implicates a specific factor (Nrf2) in premature aging of the blood vessels, as well as their improper healing. Expanding on this study Nutri-Med Logic Corp says that Nrf2, also known as a physiological regulator of oxidative stress, plays an important part in general premature aging as well as many diseases, ranging from Arthritis to Alzheimer.

A new study, investigating the premature aging and improper healing of the blood vessels, has found that the dysfunction of a cellular factor (Nrf2) to be an underlying cause of the impaired blood vessel formation (angiogenesis) and its subsequent improper healing and premature aging. Expanding on this study, Nutri-Med Logic Corp states that a key target for activation of Nrf2 is to increase the production of an internal anti-oxidant, Glutathione, colloquially referred to as anti-aging anti-oxidant, which decreases by age.

Prior to this new study, the most notable study in premature cellular aging was done by Dr. Farzaneh-Far of San Francisco General Hospital, published in Journal of American Medical Association, where Dr. Farzaneh-Far found an association between the consumption of anti-inflammatory nutrients (Omega-3) and the extreme ends of the DNA (telomeres), as an indicator of pre-mature cellular aging. Accordingly, inflammation was and continue to be presumed as a key culpable element in normal or premature cellular aging.

However, while inflammation exerts itself as a cause but, more often than not, the inflammation could only be the symptom. Thus, distinction has to be made as to whether the cellular premature aging is due to the inflammation, per se, or that the inflammation is a manifestation of another underlying cause “Redox Imbalance”.

While the lack of anti-inflammatory nutrients could become a causative issue, as to the inflammation, but in the cases of inflammation due to oxidative stress (redox imbalance), anti-inflammatory nutrients could only offer some protective role, whereas improving the redox imbalance would directly address the cause.

This new study correctly brings to surface an important underlying cause of premature aging: Redox Imbalance, which promotes the activation inflammatory genes, via activation of the inflammation master switch (NF-kB).

While this study only discusses the premature cellular aging of the blood vessels but the redox imbalance is a matter of systemic concern, to-wit, not only it affects the cells of the blood vessels but also each and every human cell, as the activation of NF-kB through the redox imbalance is a systemic matter.

As it relates to this study, the genes are those that cause the activation of Nrf2, a cellular transcription factor. Nrf2 targets one of the most important elements in the human anti-oxidant defense (redox): Glutathione. (1)

According to The Department of Internal Medicine of University of Miami, the cellular redox is regulated by three systems, two of which are also regulated by glutathione. (2)

For reason unknown, the production of glutathione decreases by age and while glutathione is found in food, its concentration does not increase significantly either through food or through the dietary supplementation of glutathione.

In 1996, an anti-oxidant researcher at University of Berkeley, California, Dr. Packer, a professor of molecular and cell biology, discovered that R-Alpha Lipoic Acid, a nutrient, increases the production of glutathione.

R-Alpha Lipoic Acid (also known as R-Lipoic Acid) is a biologically significant (active) compound produced by human body and found in many foods. The serum concentration R-Alpha Lipoic Acid, like glutathione, does not increase from food but studies have conclusively shown that the dietary supplementation of R-Alpha Lipoic results in its detectable serum concentration.

In conclusion, Nutri-Med Logic Corp agrees with this important recent study but adds, while targeting the activation of Nrf2 is a fundamental step in correcting the redox imbalance but nutrients that are capable of achieving similar results should receive equal considerations.

Nutri-Med Logic Corp. is a producer dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid, the dietary supplement of choice for the Diabetics, in Germany for more than 40 years;

Nutri-Med Logic Corp is also the producer of the Natural, Balanced, Deodorized and Concentrated Omega-3, which is also a Pharmaceutical Grade Omega-3;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy and the recommended dietarty supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for about 50 years.

Nutri-Med Logic Corp invites you to visit its News Archives and Review other News Releases on the potential benefits of R-Alpha Lipoic and What Is Omega-3 Good For.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, sources or statements above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

1. J Neurochem. 2006 May;97(3):687-96
2. Drugs. 2011 Jul 30;71(11):1385-96

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H.R. Zadeh