Studies Associate Alzheimer to The Declining Sex Hormones With Oxidative Stress and Inflammation as The Key Players

Share Article

A newly published study states that the levels of sex hormones in men with Alzheimer is less than the men without Alzheimer and suggests sex hormones and immune system influence one another, with inflammatory stimuli as a link. Agreeing with this study, Nutri-Med Logic Corp adds that other studies have also suggested a link between sex hormones and Alzheimer in both women and men, women carrying a higher risk, but with oxidative stress as the link; thus supporting the essentiality of anti-inflammatory and anti-oxidant nutrients in the daily diet.

A newly published study that conducted a study of male sex hormones and an inflammatory, immune mechanism (TNF-Alpha) found that men with Alzheimer Disease (AD) had lower levels of free sex hormones (testosterone) than non-AD men and, further, states a positive association between the parent hormone to testosterone (LH) and inflammation.

Agreeing with this study, Nutri-Med Logic Corp adds that while the sex hormones (testosterone or estrogen) are well known for their roles in reproduction, but a large body of evidence suggest these hormones to also confer neuro-protective function in the cases of elderly AD, in part by anti-oxidative and anti-inflammatory mechanisms and that the rise in their parent hormone LH (Leutinizing) is suggested to be an attempt in normalizing their declining levels due to the biological aging; women being more disposed due to the abrupt decline in their estrogen levels after menopause. (1, 2)

While inflammation is a known risk factor for AD, but studies also support the position that increased levels of oxidative stress have been found in AD patients and same to be strongly associated with amyloid deposits. Amyloids (Beta) are molecules that are implicated in the development and the progression of AD.

Moreover, while both testosterone and estrogen confer anti-inflammatory and anti-oxidative properties on the neurons but the inherent protection against inflammation and oxidative stress is through the body’s internal anti-oxidant defense and its ability to efficiently resolve inflammation.

The cellular anti-oxidant defense is the ability of cells to counter oxidative stress (redox) and, according to The Department of Internal Medicine of University of Miami, the cellular redox is regulated by three systems, two of which are also regulated by an internal anti-oxidant called glutathione. (3)

Like the sex hormones, glutathione levels decrease by age and, thus naturally, such decline places a greater burden on any available molecule to counter oxidative stress, including but not limited to the declining sex hormones.

Overwhelming number of studies have shown that glutathione level increases through dietary supplementation of a nutrient called R-Alpha Lipoic Acid, a potent anti-oxidant by itself.

The natural resolution of inflammation in the nervous system is achieved through Resolvins Series D, a by-product of DHA Omega-3 fatty acids.

DHA Omega-3 fatty acids also produce Neuro-Protectin D-1, molecules that confer natural protection on the cells of nervous system (neurons).

While hormone replacement therapy is always an available option to increase estrogen and testosterone but a diet that would incorporate anti-inflammatory and anti-oxidant nutrients is always essential and prudent.

In conclusion, Nutri-Med Logic Corp. agreeing with new study, adds that while the decline in male sex hormones and inflammation are implicated in the development and progression of Alzheimer in men, but oxidative stress is also a key player, women always carrying a higher risk due to the abrupt estrogen decline at menopause.

Nutri-Med Logic Corp is the producer of the Natural, Balanced, Deodorized, Concentrated and Pharmaceutical Grade Omega-3.

Nutri-Med Logic Corp is also a producer of dietary supplements such as a Pharmaceutical Grade R-Alpha Lipoic Acid (the natural type of Lipoic Acid), a universal anti-oxidant and the dietary supplement of choice for the Diabetics, in Germany for decades;

Producer of PolyEnylPhosphatidylCholine (PPC 425mg), an extract of soy, a pure and effective dietary source of choline and the recommended dietary supplement for those with Fatty Liver and Alcoholic Liver Disease, in Europe for decades.

Nutri-Med Logic Corp invites you to visit its News Archives and Review its News Releases on other potential benefits of R-Alpha Lipoic Acid and What is Omega-3 Good For.

Nutri-Med Logic's products are Formulated Based on Nutritional Logic, made from the highest quality raw materials that are manufactured in pharmaceutical facilities, encapsulated in pharmaceutical facilities and packaged in pharmaceutical facilities.

It must be noted that the studies, statements or sources above or below have not been evaluated by The FDA and, thus, one should not relate the cause of any diseases, stated herein, to lack of the dietary supplements, stated herein, nor equate their supplementation to prevention, treatment or cure.

1. Exp Gerontol. 2004 Nov-Dec;39(11-12):1633-9.
2. Antioxidants & Redox signaling. Vol. 8, No. 11 & 12, 2006.
3. Drugs. 2011 Jul 30;71(11):1385-96.

Share article on social media or email:

View article via:

Pdf Print

Contact Author

H.R. Zadeh
Visit website