Using Mathematical Models to Understand Nanoscale Roughness Published by Dove Medical Press

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Fibronectin and collagen type IV adsorption studies showed a linear adsorption behavior as the surface nanoroughness increased.

International Journal of Nanomedicine has published the original research “Using mathematical models to understand the effect of nanoscale roughness on protein adsorption for improving medical devices”.

As main author Dr Ercan says “Protein adsorption is critical for the longevity of an implant. Among others, surface nanophase topography and wettability are important parameters that affect the type, amount and bioactivity of the adsorbed proteins, which, in turn controls select cellular adhesion onto biomaterial surfaces. In order to model the effect of surface nanophase topography and wettability on protein adsorption, highly ordered poly(lactic-co-glycolic acid) surfaces with identical chemistry but altered nanoscale roughness and energy were synthesized.”

Dr. Ercan continues “Fibronectin and collagen IV adsorption was assessed and observed trends were line fitted to currently used mathematical models. The results from this study provided an important step in developing future mathematical models that can correlate surface properties (such as nanoscale roughness and surface energy) to initial protein adsorption events important to promote select cellular adhesion.”

As Professor Webster, Editor-in-Chief, explains “Researchers from Northeastern University recently developed a mathematical model that can help to understand biological interactions with nanomaterials. Such results can be used to improve implant performance for a variety of tissues and reduce the number of experiments (and consequently the use of animals) in the development of improved medical devices.”

International Journal of Nanomedicine is an international, peer-reviewed journal focusing on the application of nanotechnology in diagnostics, therapeutics, and drug delivery systems throughout the biomedical field. Reflecting the growing activity in this emerging specialty, the aim of this journal is to highlight research and development leading to potential clinical applications in the prevention and treatment of disease.

Dove Medical Press Ltd is a privately held company specializing in the publication of Open Access peer-reviewed journals across the broad spectrum of science, technology and especially medicine.

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Albert Chan
Dove Medical Press
+64-9-443 3060 Ext: 202
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