Ethical Alternative Products Releases a Statement on New Alpha Lipoic Acid Study

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Fructose administration rapidly induces oxidative stress that triggers compensatory hepatic metabolic changes leading to increased blood levels of insulin and triglycerides and increased insulin resistance.

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control of oxidative stress could be a useful strategy to prevent transition from impaired glucose tolerance to type 2 diabetes.

A study* performed by Castro, M.C. et al. on rats was undertaken to determine if the oxidative stress induced changes in liver carbohydrate metabolism could be prevented by the co-administration of a racemic form of alpha lipoic acid. Rats fed fructose alone had increased blood levels of glucose, insulin, and triglycerides and higher insulin resistance, and showed increased fructokinase gene expression in liver cells. All of these changes were prevented by alpha lipoic acid co-administration.

The authors conclude that fructose induces hepatic metabolic changes that attempt to switch the substrate flow from mitochondrial metabolism to energy storage, and that these changes can be effectively prevented with alpha lipoic acid co-administration. The authors further conclude that control of oxidative stress could be a useful strategy to prevent transition from impaired glucose tolerance to type 2 diabetes.

“Oxidative stress can be reduced by limiting fructose intake (Eg., high fructose corn syrup) and by making lifestyle changes that increase food-based anti-oxidants and by exercising regularly” stated Gerald Bruno, Ph.D., CEO of Ethical Alternative Products. “These lifestyle changes can be complemented and enhanced with the use of alpha lipoic acid in supplement form. The ThioGel brand of alpha lipoic acid manufactured by Ethical Alternative Products is solubilized for enhanced absorption and bioavailability and is packaged in easy to swallow softgel capsules. Highest quality raw material alpha lipoic acid that is sourced from Europe is used to make the ThioGel product”, stated Bruno.

About Ethical Alternative Products
Ethical Alternative Products is a dietary supplement supplier that is focused on the formulation of scientifically sound natural products that can make a meaningful difference in achieving and maintaining overall well-being, especially with aging. The mission of our senior scientific management is to develop and produce high-value supplements, employing innovative formulations and highest quality raw materials. Products produced by Ethical Alternative Products include ThioGel liquid gel alpha lipoic acid, ThioGel-L triple antioxidant liver formulation, OmniFlex multi-nutrient joint health product and Tendonex topical pain reliever.

*Lipoic acid prevents fructose-induced changes in liver carbohydrate metabolism: Role of oxidative stress.
Castro MC, Francini F, Gagliardino JJ, Massa ML. Biochim Biophys Acta. 2014 Mar;1840(3):1145-51

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Monica Adametz
Ethical Alternative Products
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