Drug May Boost NHL Chemotherapy
SNS01-T...synergizes with the current therapies bortezomib and lenalidomide to inhibit tumor progression.
Raleigh, NC (PRWEB) March 10, 2014
The Non-Hodgkin’s Lymphoma Center is reporting on new published research on an experimental Non-Hodgkin’s Lymphoma drug that appears to boost the power of existing medications.
SNS01-T is a mixture of nanoparticles designed to interfere with the inner workings of malignant B-cells in patients with Non-Hodgkin’s Lymphoma and other B-cell cancers. A new study on the compound in Molecular Therapy, the official journal of the American Society of Gene Therapy, finds that it has the power to induce apoptosis (programmed cell death) in cancer B-cells, especially if it is combined with the active ingredients in two popular Non-Hodgkin’s Lymphoma drugs, Revlimid (lenalidomide) and Velcade (bortezomib).
Researchers in Canada and New Jersey who conducted the laboratory and animal tests on SNS01-T say the compound was taken up by several kinds of cancerous B-cells, including multiple myeloma, the second most common hematological malignancy after Non-Hodgkin’s Lymphoma. At higher doses, the drug was also found to inhibit tumor growth up to 90% in animals with diffuse large B-cell lymphoma, the most common type of Non-Hodgkin’s Lymphoma in adults. Importantly, it did not have a significant effect on normal B-cells.
“In this study we show that SNS01-T is preferentially taken up by malignant B-cells, inhibits tumor growth in multiple animal models of B-cell cancers without damaging normal tissues, and synergizes with the current therapies bortezomib and lenalidomide to inhibit tumor progression,” the authors write in a summary of their research.
When a combination of SNS01-T and Revlimid was given to mice with Non-Hodgkin’s Lymphoma, all of them survived, compared to just 20% for Revlimid alone. Sixty-seven percent of the animals experienced eradication of their cancer after a single 6-week cycle of the combination and, at 8 weeks, there was no recurrence of Non-Hodgkin’s Lymphoma or the other cancers tested. The combination of SNS01-T and Velcade reportedly inhibited cancer growth in the mice by 89%, compared to 39% for Velcade alone.
The original study results were published in Molecular Therapy. (Francis, SM, “SNS01-T modulation of 3lF5A inhibits B-cell cancer progression an synergizes with bortezomib and lenalidomide”, February 26, 2014, Molecular Therapy, Epub ahead of print, http://www.ncbi.nlm.nih.gov/pubmed/?term=SNS01-T)
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