Boston Area Pharmaceutical Formulation Development Firm and CRO Integral BioSystems CEO/CTO Dr. Shikha Barman Named “One of the 20 Women to Watch in 2014”

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Dr. Shikha Barman, Chief Executive Officer and Chief Technology Officer of the startup Boston-area specialty pharmaceutical formulation development firm and CRO Integral BioSystems LLC, will be awarded the prestigious title of “One of the 20 Women to Watch in 2014” by Mass High Tech on May 8, 2014 at the Sheraton Boston Hotel.

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Dr. Shikha Barman

Boston Massachusetts Specialty Pharmaceutical Formulation Development Firm Integral BioSystems LLC Founder and CEO/CTO Dr. Shikha Barman to be feted as “One of the 20 Women to Watch in 2014” by Mass High Tech.

Under the guidance of Dr. Barman, Integral BioSystems LLC began its operation as a pharmaceutical formulation developer and CRO in less than 200 square feet of subleased laboratory space with one employee. Less than four years later, the firm now has its own 3,500 square foot facility filled with its own state of the art equipment and 9 full-time employees.

Accordingly, the award from Mass High Tech acknowledges her achievements as both a scientist and businesswoman in the Boston area as the entrepreneurial head of a cutting-edge pharmaceutical formulation development firm producing state-of-the-art microparticulate and nanoparticulate-based drug dosage forms, both under contract for third parties as well as for her firm’s own products, OcuSurf™ and EySite™. OcuSurf™ is Integral BioSystems’ novel, front-of-the-eye platform designed to enhance the persistence and bioavailability of ophthalmic formulations, while EySite™ offers a new approach to back-of-the-eye treatments to minimize their negative effects.

Responsible for both the business direction and technical guidance of the firm, Dr. Barman has approximately 20 years of work experience in the pharmaceutical and biotech industries in areas of drug delivery, pharmaceutical development and tissue engineering. Her interests have always been entrepreneurial, selecting the start-up venture over established companies, choosing to accept high risk in exchange for exponential professional growth usually experienced in innovative product development.

Also an artist and musician, Dr. Barman has always been fascinated by the considerable overlap in the creative process required in both the arts and the hard sciences. In particular, she perceives a similar need for creativity in the endeavors, there being considerable overlap between the processes of producing a work of art and a novel drug delivery formulation.

Her initial major contributions after completing her dual-Ph.D. program in Chemistry at the University of Massachusetts in Lowell, Massachusetts were at the startup biomaterials firm Focal, Inc., where she invented novel approaches and made creative contributions to the design and development of a platform technology of PEG-based photocrosslinkable, biodegradable tissue sealants, the entire line of which was acquired by Genzyme BioSurgery. She has also contributed to core intellectual property in subsequent positions at the startup firms Zycos, Inc., Sontra Medical Corporation, Inotek Corporation and Follica, Inc. Her roles have been increasingly multidiscipline with each successive company that she worked in, with cross-functional job responsibilities in CMC, pharmaceutical development, preclinical and toxicology.

Under Dr. Barman’s guidance, Integral BioSystems has developed numerous dosage forms for ophthalmic, oral, sublingual, intranasal, IV and transdermal routes, always taking a translational approach to drug development, customizing delivery systems to achieve the biologically effective objectives of the therapy. Dosage forms are customized to achieve sustained release or targeted, tissue-focused delivery or fast-release/instant delivery, depending upon the desired product attributes.

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