Toronto, Canada (PRWEB) April 18, 2014
The study of phosphoproteomics represents a major leap forward in drug target and mode of action analysis: Deregulated protein kinase signaling occurs in many human diseases such as cancer, inflammatory disorders or neurodegenerative disease. Knowledge about cellular modes of action is of key importance for the successful development of kinase-selective drugs. Evotec’s phosphoproteomics technology PhosphoScout® provides an unbiased approach to investigate molecular mechanisms of kinase inhibition, as it allows the reliable measurement of more than 10,000 phosphorylation sites in living cells, animal models and patient samples.
Dr. Henrik Daub, Senior Vice President of Science & Technology at Evotec will provide insight on how PhosphoScout® technology utilizes quantitative mass spectrometry and bioinformatics to investigate and signaling pathways and mechanisms on a global scale. Typical applications are:
- Applying phosphoproteomics studies for the selection of drug candidates with maximal on- and minimal off-target activity in cellular conditions, either as single agents or in combination with other drugs
- Monitoring phosphoproteome regulation in different biological models to shed light on factors underlying differential biological activity of kinase-selective drugs
- Using phosphoproteomics studies for the identification of pharmacodynamic biomarkers for therapeutic kinase inhibition
For more information on this webinar or to register, visit: Quantitative Phosphoproteomics to Support the Discovery and Development of Kinase-selective Drugs
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