Toronto, Canada (PRWEB) April 29, 2014
Using phenotypic screens as a strategy to identify potential drug candidates has gained renewed attention in recent years. The aim is to identify chemical matter that corrects disease-relevant cellular phenotypes with the potential to be truly disease-modifying. To this end, Evotec has established innovative and novel disease-relevant screening paradigms.
Join speakers Dr. Mark Slack, Vice President of In Vitro Pharmacology at Evotec, and Dr. Stefan Müller, Head of Chemical Biology at Evotec as they describe their unique approach. Understanding the mechanism and binding partner(s) of any hit compounds identified from phenotypic screening has posed a challenge for many years. Evotec’s Cellular Target Profiling™ approach combines quantitative mass spectrometry based chemical proteomics to identify the target(s) of small molecule hit compounds. The technology uses cells to reveal a compound’s cellular binding partners including binding affinities thus allowing deciphering the network of intracellular targets and enabling lead optimization.
The webinar will focus on:
- Use of novel disease-relevant cellular systems for hit ID including the use of stem cells
- Characterization and prioritization of hits for target identification post HTS
- Target deconvolution through mass spec-based Cellular Target Profiling
For more information on this webinar or to register, visit: Integrated Phenotypic Screening and Target Deconvolution for Accelerated Drug Discovery.
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