What is the Second Leading Cause of Cancer; The CBCD Reviews Surprising Data

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“Epidemiological data imply that viruses are the second most important risk factor for cancer,” according to a study published on June 6, 2014 in the Journal of Neurology, Neurosurgery, and Psychiatry (1). The Center for the Biology of Chronic Disease (CBCD) reviews the medical literature and explains the relationship between cancer and Dr. Hanan Polansky’s discovery.

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Dr. Polansky’s work explains how foreign DNA fragments, created by latent viruses, can cause cancer, and other chronic diseases. - CBCD

Science may be finally catching up to the ground breaking ideas presented in Dr. Hanan Polansky’s book, “Microcompetition with Foreign DNA and the Origin of Chronic Disease,” which was published more than 10 years ago. Doctor Dey and his team of researchers suggest that “Epidemiological data imply that viruses are the second most important risk factor for cancer (1).” Yet, Dr. Polansky’s work in 2003 identified latent viruses as the “origin of many chronic diseases, such as cancer, atherosclerosis, stroke, obesity, diabetes, multiple sclerosis, lupus, thyroiditis, osteoarthritis, rheumatoid arthritis, and alopecia.” (See Microcompetition with Foreign DNA and the Origin of Chronic Disease, published in 2003) (2) Specifically, Dr. Polansky’s work explains how foreign DNA fragments, created by latent viruses, can cause these, and many other major diseases. The book has been read by more than 5,000 scientists around the world, and has been reviewed in more than 20 leading scientific journals.

Dr. Dey and his colleagues further wrote that “Although the ability of certain viruses (hepatitis B and C, human papillomavirus, etc) to cause cancer has been time tested and proven scientifically, there are several other potential viral candidates whose role in oncogenesis (development of cancer) is more controversial (1).” These candidates are listed in Dr. Polansky’s book. They include the herpesvirus family of viruses (HSV-1, HSV-2, EBV, CMV, VZV, HHV-6, HHV-7 etc.), and the Human Immunodeficiency Virus (HIV) (2). Dr. Polansky’s book also explains why these viruses, and not others, cause cancer.

Dr. Polansky’s theory, discusses how these latent viruses that include foreign DNA fragments called N-boxes, are causing most major diseases. For example, “The theory describes the effect of Foreign DNA fragments that include the cis-regulatory element, called an N-box, on transcription of cellular genes. Consider foreign N-boxes that entered the body naturally, through, for instance, an infection or digestion, or artificially, through, for instance, an injection of some treatment. The foreign N-boxes attract the transcription complex GABP∙p300. Since the complex is a scarce genetic resource, the foreign N-boxes decrease the availability of this complex to cellular genes.” (2)

What is the result of Microcompetition?

The genes that are transactivated by the GABP∙p300 complex produce fewer proteins, and the genes that are suppressed by this complex produce more proteins. The abnormal levels of these cellular proteins cause a disease. It is interesting that many common viruses that establish a latent infection have strong N-boxes in their promoter/enhancer. They include the Epstein-Barr virus (EBV), Cytomegalovirus (CMV), Herpes Simplex virus (HSV), Varicella Zoster virus (VZV), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), and the Human Papillomavirus (HPV). In fact, the CMV has the strongest promoter/enhancer known to science. Liu et al. showed that the CMV promoter/enhancer, which includes the N-box, is more than 150-fold stronger than the promoter of the platelet-derived growth factor-b chain (PDGF-b) gene.” (See Pharmacology & Pharmacy, from March 2014) (3). The Microcompetition theory predicts that a latent infection with CMV will cause a decrease in PDGF-b transcription, a decrease in the concentration of the PDGF-b protein, and disease.

For a better understanding of latent viruses and their impact on chronic disease processes, including cancer, the CBCD encourages government officials, healthcare managers, physicians, virologists, biologists, geneticists, and scientists to obtain a copy of Dr. Hanan Polansky's book and read it. A free copy of the book can be downloaded from the CBCD website here: http://www.cbcd.net/Book.php.

Dr. Polansky’s book received high praise from leading scientists. For example, Dr. Sivasubramanian Baskar, PhD of the United States National Cancer Institute (NIH) said “I wish to congratulate Dr. Hanan Polansky for his scientific bravery to take such a unique, novel approach to further stimulate our understanding of the origin and establishment of chronic diseases. The philosophy underscored is an excellent one ... The amazing correlation between theoretical predictions and observed in vivo effects seem to bring us a step closer to a deeper understanding of such complex biologic processes.” (See the CBCD, from 2008) (4). More than fifty additional reviews recommending the book can be found here: http://www.cbcd.net/reviews.htm.

The CBCD endorses Dr. Polansky’s theory and invites interested parties to contact us on this issue.

For more information on the Center for the Biology of Chronic Disease, or to schedule an interview with Dr. Polansky, please visit http://www.cbcd.net or call 585-250-9999.


(1)    Cytomegalovirus and glioma: putting the cart before the horse. Published on June 6, 2014. http://www.ncbi.nlm.nih.gov/pubmed/24906494
(2)    Microcompetition with Foreign DNA and the Origin of Chronic Disease. Published 2003. http://www.cbcd.net/Book.php
(3)    Gene-Eden-VIR is Antiviral: Results of a Post marketing clinical study. Published in September 2013. http://www.scirp.org/journal/PaperInformation.aspx?PaperID=36101#.U6KOppSSz90
(4)    CBCD Book Reviews http://www.cbcd.net/reviews.htm

The Center for the Biology of Chronic Disease (CBCD, http://www.cbcd.net) is a research center recognized by the IRS as a 501(c)(3) non-for-profit organization. The mission of the CBCD is to advance the research on the biology of chronic diseases, and to accelerate the discovery of treatments for these diseases.

The CBCD published the “Purple” book entitled “Microcompetition with Foreign DNA and the Origin of Chronic Disease” written by Dr. Hanan Polansky. The book presents Dr. Polansky’s highly acclaimed scientific theory on the relationship between the DNA of latent (chronic) viruses and the onset of chronic diseases.

Dr. Polansky’s book is available as a free download from the CBCD website.

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Hanan Polansky
Center for the Biology of Chronic Disease (CBCD)
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