United States (PRWEB) July 08, 2014
The Glioblastoma Multiforme (GBM) treatment market is forecast to grow rapidly from $301 million in 2013 to $623 million by 2020, at a Compound Annual Growth Rate (CAGR) of 10.9%. Reportstack's latest report on Glioblastoma Multiforme Therapeutics in Major Developed Markets to 2019 states that this significant growth comes despite the patent expiration of Temodar (temozolomide) and will be driven primarily by the market entry of the DCVax-L vaccine. This follows clinical trials showing that DCVax-L produces an Overall Survival (OS) of around 2.3 times longer than the current standard of care for newly diagnosed patients.
Angel Wong, Analyst for GBI Research, says: “The current standard treatment of surgery, radiotherapy and chemotherapy, in combination with Temodar, has an OS of less than 15 months. As DCVax-L has been shown to extend OS substantially, the vaccine will demand a premium price once it hits the market.” The study expects DCVax-L, which has recently received early approval in Germany, to be approved in the US and EU in 2015 and 2016, respectively, ahead of less efficacious treatments Cotara and Rindopepimut (CDX-110), which will enter the global GBM treatment market in 2016 and 2017, respectively.
DCVax-L has the added advantage of facing few other active competitors in the current GBM therapeutics market, the investment in which is regarded as high-risk. Wong explains: “Clinical trials for new GBM treatments are extremely time consuming and have a high attrition rate. There are limitations in drug delivery techniques and the disease has low prevalence rates, making trial recruitment difficult. As a consequence, drug development is very costly. However, there remains a significant demand for therapies that show high potency against chemotherapy-resistant tumors, due to the limited OS benefits provided by current treatments. As such, there are some attractive opportunities, particularly for recurrent GBM, as the unmet needs of these patients are not expected to be addressed by current players in the market.”
The companies mentioned in this report are Merch, Roche, Bristol-Myers Squibb, Eisai. The marketed drugs mentioned in this report are Temodar (temozolomide), Avastin (bevacizumab), BiCNU (carmustine) and Gliadel Wafer (carmustine in polifeprosan). More details about this report can be viewed by visiting Glioblastoma Multiforme Therapeutics report.
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