The expression of latency genes is associated with malignancy. - Dr. Yau (1)
Rochester, NY (PRWEB) September 03, 2014
Research shows that 10% of all stomach cancers are caused by the presence of the Epstein Barr Virus (EBV). EBV stomach cancers have unique characteristics. Dr. Yau and colleagues wrote that these cancers exhibit “male predominance (and) lower rates of lymph node involvement.” (1) Importantly, Dr. Yau noted that “the expression of latency genes is associated with malignancy.” Unlike the scientists at The Center for the Biology of Chronic Disease (CBCD), most members of the medical community still believe that latent viruses are inactive and therefore harmless. However, Dr. Yau’s study showed, as predicted by the Microcompetition with Foreign DNA Theory, that the latent EBV promotes tumor progression.
Another study placed emphasis on the role of latent EBV in cancer. “…latent infection can drive the formation of Burkitt’s lymphoma (BL), Hodgkin lymphomas, nasopharyngeal carcinoma (NPC), and gastric carcinoma (GC). Latent infection with EBV is a major cause of post-transplant lymphoproliferative disease in immunosuppressed patients and greatly enhances risk of developing non-Hodgkin and primary CNS lymphomas in the HIV-positive population.” (See ACS Chemical Biology, from March 2014) (2)
The authors are very clear. Latent EBV causes cancer. “Most EBV associated cancers contain viral DNA that exists predominantly as a latent infection in which only a limited set of viral genes are expressed. These latency associated genes are implicated in host-cell proliferation and survival, and latent EBV can directly promote tumor progression.” (2)
Some doctors argue that latent viruses are inactive, that is, they show no transcription (production of proteins) and no shedding. Since the virus is inactive it is harmless. In contrast, a paper entitled “Human Cytomegalovirus Persistence” published February 13, 2012 in the journal Cellular Microbiology, clearly says that latent viruses are active. “Both the chronic and latent states of infection contribute to HCMV persistence and to the high HCMV seroprevalence worldwide. The chronic infection is poorly defined molecularly, but clinically manifests as low-level virus shedding over extended periods of time and often in the absence of symptoms.” (See Cellular Microbiology, from March 2012) (3) Note how the paper describes viral shedding during latency.
Moreover, another study said that “Transcripts and proteins encoded from a region encompassing the major immediate early region are detected in hematopoietic cells following infection in vitro as well as in latently infected individuals.” (See the Proceedings of the National Academy of Sciences, USA, from 1996) (4) This means that there is transcription that occurs during latency.
Why should the public care about latent viruses? The answer is that almost everyone is infected with a latent virus. In other words, almost everyone is at risk of a major disease. “EBV is found all over the world. Most people get infected with EBV at some point in their lives. “ (See the CDC, last updated on January 6, 2014) (5)
“We believe that it is time for the medical community to change its way of thinking, as it is clear that the evidence supports the role of latent viruses in the pathogenesis of major diseases.” – Greg Bennett, CBCD
The following is a simplified explanation of that theory. Dr. Hanan Polansky discovered that foreign DNA fragments, called N-boxes, cause most major diseases. When the foreign N-boxes belong to a virus, microcompetition between the viral DNA and the human DNA can lead to disease even when the virus is latent or the viral DNA is broken into pieces and cannot express proteins.
Why do only a few infected people actually develop a major disease at any given time?
The answer is, according to Dr. Polansky’s Microcompetition Theory, only those with a high concentration of latent viruses develop a disease. Who are these people? They are people who have a decline in the immune system. There are many reasons for a decline in the immune system includeing: stress, aging, medications, medical procedures, radiation, X-rays, sunlight, and even cell phone radiation.
To learn more about Dr. Hanan Polansky’s research and the Theory of Microcompetition with Foreign DNA, visit: http://www.cbcd.net
References:
(1) Yau TO, Tang CM, Yu J. Epigenetic dysregulation in Epstein-Barr virus-associated gastric carcinoma: disease and treatments. World J Gastroenterol. 2014 Jun 7;20(21):6448-56.
http://www.ncbi.nlm.nih.gov/pubmed/24914366
(2) Tikhmyanova N1, Schultz DC, Lee T, Salvino JM, Lieberman PM. Identification of a new class of small molecules that efficiently reactivate latent Epstein-Barr Virus. ACS Chem Biol. 2014 Mar 21;9(3):785-95.
http://www.ncbi.nlm.nih.gov/pubmed/24028149
(3) Felicia Goodrum,1,2,3 Katie Caviness,3, and Patricia Zagallo1, Human Cytomegalovirus Persistence, Cell Microbiology. Published May 2012. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3330195/#__ffn_sectitle
(4) Kondo K1, Xu J, Mocarski ES. Human cytomegalovirus latent gene expression in granulocyte-macrophage progenitors in culture and in seropositive individuals. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):11137-42.
http://www.ncbi.nlm.nih.gov/pubmed/8855322/
(5) CDC.com - About Epstein-Barr Virus (EBV). Last updated January 6, 2014. http://www.cdc.gov/epstein-barr/about-ebv.html
The CBCD is a research center recognized by the IRS as a 501(c)(3) non-for-profit organization. The mission of the CBCD is to advance the research on the biology of chronic diseases, and to accelerate the discovery of treatments.
The CBCD published the “Purple” book by Dr. Hanan Polansky. The book presents Dr. Polansky’s highly acclaimed scientific theory on the relationship between foreign DNA and the onset of chronic diseases. Dr. Polansky’s book is available as a free download from the CBCD website.