New Mesothelioma Study Says Mice Cured by Immuntherapy “Cocktail”, Reports Surviving Mesothelioma

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Australian researchers say they have cured mesothelioma in lab mice by giving them a combination of three immune system antibodies.

Antibody Combo Cures Mesothelioma in Mice

Immunotherapy "Cocktail" for Mesothelioma

We think it is especially exciting news for mesothelioma patients, who have such limited treatment options.

Scientists at the University of Western Australia say a combination of three drugs that target immune system proteins has the power to knock out mesothelioma in mice. Surviving Mesothelioma has just posted details of the new study on their website. Click here to read the story now.

Researchers in the UWA School of Pathology and Laboratory Medicine administered anti-CD25, anti- TGF-β, and anti-CTLA-4 drugs to mice with mesothelioma with promising results.

“A timed triple immunotherapy protocol using 3 agonist antibodies produced complete clearance of established AB1 murine mesothelioma tumors,” reports Shruti Krishnan, lead author of the study.

The new research, published in the Journal of Interferon and Cytokine Research, suggests that the mesothelioma treatment was equally effective, whether the antibodies were delivered together or one-at-a-time.

“While this immunotherapy study has implications for a number of different cancers, we think it is especially exciting news for mesothelioma patients, who have such limited treatment options,” says Alex Strauss, Managing Editor of Surviving Mesothelioma.

For more on immunotherapy and what these findings may mean for patients and their families, see Immunotherapy “Cocktail” Destroys Mesothelioma Tumors in Lab Mice, now available on the Surviving Mesothelioma website.

Krishnan, S et al, “Successful Combined Intratumoral Immunotherapy of Established Murine Mesotheliomas Requires B-Cell Involvement”, September 26, 2014, Journal of Interferon and Cytokine Research, Epub ahead of print,

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Cancer Monthy
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