Research Finds BAP1 Rarely the Sole Cause of Mesothelioma, According to Surviving Mesothelioma

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European scientists say there are almost always other factors involved when people with the BAP1 genetic mutation develop malignant pleural mesothelioma.

Sporadic Mesothelioma Rarely Triggered by BAP1

BAP1 Mutation and Mesothelioma

The prevalence of germline BAP1 mutations in sporadic malignant pleural mesothelioma patients can be estimated about 1-2%...

Researchers from Switzerland, Belgium, and Italy have all reached a similar conclusion in recent months on the role of the BAP1 genetic mutation in malignant pleural mesothelioma. Click here to read the full story on the Surviving Mesothelioma website.

In the most recent study on BAP1 and mesothelioma, scientists with University Hospital of Zurich and University Hospitals, Leuven, Belgium concluded that non-asbestos-related or “sporadic” mesothelioma cases are rare when the only risk factor is a BAP1 genetic mutation.

“The prevalence of germline BAP1 mutations in sporadic malignant pleural mesothelioma patients can be estimated about 1-2%, suggesting a minor role…in the pathogenesis of sporadic MPM,” writes Swiss author Andreas Rusch.

The report, published in the journal Lung Cancer, is similar to a recent Italian study that also found BAP1 mutations to be “very rare” in sporadic mesothelioma.

“While these findings may be encouraging to those with the BAP1 mutation, these studies highlight the fact that the real cause of sporadic mesothelioma remains largely a mystery and deserves further study,” says Alex Strauss, Managing Editor of Surviving Mesothelioma.

For more on the connections between BAP1 and mesothelioma, see BAP1 Mutation Unlikely to Trigger Sporadic Mesothelioma, now available on the Surviving Mesothelioma website.

Rusch, A et al, “Prevalence of BRCA-1 associated protein 1 germline mutation in sporadic malignant pleural mesothelioma cases”, November 6, 2014, Lung cancer, Epub ahead of print,

Betti, M, “Inference on germline BAP1 mutations and asbestos exposure from the analysis of familial and sporadic mesothelioma in a high-risk area”, Sept. 18, 2014, Gene, Chromosomes & Cancer, Epub ahead of print,

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Cancer Monthy
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