The addition of vitamin B12 and folic acid to platinum-containing regimens did not overall improve the toxicity...
Raleigh, NC (PRWEB) January 10, 2015
British researchers say the practice of giving chemotherapy patients supplements of B12 and folic acid may be not doing enough to ward off a serious side effect. Surviving Mesothelioma has the full story on its website. Click here to read it now.
Doctors at the Royal Marsden Hospital in Sutton, UK studied 83 patients with advanced lung cancer or pleural mesothelioma who were on non-pemetrexed platinum-based chemotherapy. Half of the patients received supplements to reduce the risk of neutropenia, a drop in white blood cells that increases infection risk.
“The addition of vitamin B12 and folic acid to platinum-containing regimens did not overall improve the toxicity, quality of life or overall survival,” writes Dr. Mary O’Brien, one of the study’s authors.
In fact, according to the study in BMJ Open Respiratory Research, only 25% of mesothelioma and lung cancer patients on the supplements experienced a drop in homocysteine, an amino acid that increases the risk of neutropenia.
“Since most mesothelioma patients will be on chemotherapy at some point, it is vital that they understand serious risks such as neutropenia and potential ways of avoiding them,” says Alex Strauss, Managing Editor of Surviving Mesothelioma.
For more on vitamin supplementation and mesothelioma chemotherapy, see Mesothelioma Chemotherapy: Can Supplements Make it Safer?, now available on the Surviving Mesothelioma website.
Minchom, AR et al, “An unblinded, randomised phase II study of platinum-based chemotherapy with vitamin B12 and folic acid supplementation in the treatment of lung cancer with plasma homocysteine blood levels as a biomarker of severe neutropenic toxicity”, December 11, 2014, BMJ Open Respiratory Research, http://bmjopenrespres.bmj.com/content/1/1/e000061.abstract
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