Vital Health, Inc. Unravels The Importance Of The MTHFR and MTRR Genes and Provides Tips On How To Identify, and Support The Body If the Genetic Mutations Are Present

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Methylenetrhydrofolate reductase (MTHFR) and 5-methyltetrahydrofolate-homocysteine methyltransferase reductase (MTRR) are critical genes in the body and when gene mutations are present, can affect nearly every cell in the human body.

Through the non-invasive EVA Screening, Dr. Griffin is able to test for over 300 food and environmental sensitivities, as well as evaluate for any nutritional deficiencies.

Inherited gene mutations are a person’s weakness and may increase their vulnerability to certain disease processes, especially when coupled with other triggers such as an environmental toxin, nutrient deficiency or undetected food allergies

“You cannot change gene mutations, but you can help it do its job better and minimize problems,” began Barbara Griffin, NMD, CNC, Certified Gluten Practitioner, and Director of Vital Health, Inc.

“Inherited gene mutations are a person’s weakness and may increase their vulnerability to certain disease processes, especially when coupled with other triggers such as an environmental toxin, nutrient deficiency or undetected food allergies all of which cause stress to the body,” add Dr. Griffin.

Through the Vital Health’s EVA screening and by evaluating the body’s stress level and vitamin deficiencies, Dr. Griffin is able to identify the client’s possibility of having MTHFR and MTRR gene mutations. If the gene mutations are suspected, Dr. Griffin can recommend specific MTHFR and MTRR testing along with proper supplements to further support the body.

Function Of MTHFR and MTRR Genes
MTHFR gene begins a multi-step chemical breakdown process, which is known as Methylation and occurs in every cell of the human body. Methylation occurs when the body takes one substance and turns it into another, so it is detoxified and can be excreted from the body. When methylation pathways are functioning properly, it means the body has a better chance in eliminating toxins and heavy metals, which can reduce a person’s risk for cancer and other health issues. Simply the body takes B12, Folic Acid and B6, methylates (breaks down for absorption), to make antioxidants for the liver. If a person can’t methylate they end up with high levels of inflammation in the body.

The methylation process is responsible for

  • Cellular Repair: synthesis of nucleic acids, production and repair of DNA and RNA.
  • Detoxification Neurotransmitter Production: interconversion of amino acids
  • Healthy Immune System Function: formation and maturation of red and white blood cells and platelet production.

MTRR is involved in the reductive regeneration of cob(I)alamin (vitamin B12) cofactor required for the Maintenance of methionine synthase in a functional state. The MTRR mutation is a defect of the methionine synthase reductase gene. A mutation of the MTRR gene results in poor methylation of vitamin B12. Serum B12 levels may be normal in MTRR individuals; however, the under-methylation of vitamin B12 may result in elevated homocysteine levels. High homocysteine levels may be due to the MTRR mutation.

Variations of MTHFR Gene
The type of MTHFR variation a person has may lead to a greater susceptibility to certain diseases. There are over fifty known MTHFR variants; the two primary ones are called C677T and A1298. For example, the C677T mutations may predispose one towards cardiovascular disease, peripheral neuropathy, and birth defects. Where as variations of the A1298T may lead more towards the development of fibromyalgia, schizophrenia, migraines, nerve pain, Parkinson’s chronic fatigue and dementia. The MTHFR anomaly is reported out as heterozygous or homozygous. Heterozygous means that one parent has passed down one affected gene and one normal gene. MTHFR enzyme activity will run at about 60% efficiency compared to a normal. A homozygous MTHFR means that both parents have passed down abnormal copies of the gene. As a result, enzyme efficiency drops down to 10% to 20% of normal, which can be very serious. The worst combination is 677T/1298C in which a person is heterozygous to both anomalies. Many chronic illnesses are linked to this anomaly. Fibromyalgia, irritable bowel syndrome, migraines, chemical sensitivity, frequent miscarriage and frequent blood clots are all conditions associated with MTHFR anomaly.

During the EVA Screening, Dr. Griffin will be ableto determine if the body is deficient in folate and Methl B12, which is directly tied to MTHFR and MTRR mutations. Taking the proper supplements will directly help the enzyme process work more effectively and minimize problems.

Methylcobalamin is the Preferred Form of B12
The MTRR mutation can be addressed by taking Methyl-B12 supplements, usually in doses of 1,000-5,000 mcg per day. There are many options to consider, but it is important to distinguish between methylated forms of B12 versus the more common B12 supplements. Most B12 supplements contain cyanocobalamin, which does not benefit someone with the MTRR mutation. Make sure the form of B12 you take contains methylcobalamin.

L-Methylfolate The Preferred Form of Folate
Folate is a general term for a family of structurally and functionally related water soluble B vitamins. However some individuals do not effectively convert folic acid into its active form, thus they are still at risk of deficiency. Dr.Griffin explained, “L-5methyltetrahydrofolate (L-5-MTHF) is the predominate form of folate. L-5-MTHF is a reduced, metabolically active form of folate that occurs naturally in foods and is the primary form of folate found in the blood and tissues. As a result, it is far more effective for people who have or are prone to a folic acid deficiency.” Dietary supplements MethylFolate and Methyl-B-12 Lozenges are available through the VitalEssence supplement line offered at Vital Health, Inc.

Additional MTHFR Testing
If appropriate, Dr. Griffin can assist the client complete additional MTHFR and MTRR genetic testing. Once the results are obtained, she can review the data and make appropriate recommendations.

Vital Health, Inc. recommends talking to your physician before beginning any supplement regime.

About Vital Health, Inc.:
At Vital Health, Inc. Dr. Griffin integrates a whole body approach with the intention of facilitating wellbeing and optimal health amongst her clients. Dr. Griffin’s specialties include: traditional naturopathy, nutrition, EAV Meridian Stress Assessment, Food Sensitivity Screening, Environmental Screenings,
Iridology, SKASYS, Live Blood Cell Analysis as well as established integrative therapies such as Neuroemotional Therapy, Neuromodulation Technique, Cold Laser and clinician for Spectracell Laboratories, Inc. Vital Health, Inc. is located within the office complex of the Orland Park Crossing, 14225 S. 95th Avenue Suite 409, Orland Park IL, 60462. 708-226-1131. http://www.vitalhealth.org

Sources:
(1) http://www.stopthethyroidmadness.com/mthfr/
(2) http://www.stopthelymelies.com/stll-blog/2

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Linda Gardner
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