New PAT Technique Developed By METTLER TOLEDO Indicates How Particle Size, Shape and Concentration Change in Real Time

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Relative Backscatter Index (RBI) is innovative Process Analytical Technology (PAT) technique that indicates how particle size, shape and concentration changes in real time under actual process conditions. RBI is now available to METTLER TOLEDO ParticleView V19 with PVM technology users.

Relative Backscatter Index

Relative Backscatter Index

Automatically combined with high resolution real-time microscopy images, RBI provides a simple, yet informative, process measurement that can be used to understand, optimize and control complex particle systems.

METTLER TOLEDO is pleased to announce that the Relative Backscatter Index (RBI) technique is now available. Developed by METTLER TOLEDO for scientists developing and manufacturing particles, crystals and droplets, RBI is a new PAT technique that shows how particle size, shape and concentration change in real-time.

Unlike turbidity measurements which lack sensitivity and can be difficult to interpret, RBI is an image-based measurement that utilizes real-time microscopy to accurately determine particle system reflectivity in-process. RBI is used to study changes in particle size, shape and concentration. Automatically combined with high resolution real-time microscopy images, RBI provides a simple, yet informative, process measurement that can be used to understand, optimize and control complex particle systems.

RBI is available to users of METTLER TOLEDO ParticleView 19 with PVM technology. Combined with real-time microscopy, RBI is an innovation in real-time measurement that combines simplicity with information-rich understanding to provide an easy-to-use technique supporting the development of quality processes in less time at lower costs.

Common RBI applications include solubility and metastable zone width determination (MZWD) for crystallization development; comparing crystallization rate under different process conditions; identifying the endpoint and equilibrium state for particle processes; characterizing process events such as secondary nucleation, droplet coalescence or particle breakage.

About METTLER TOLEDO
METTLER TOLEDO provides the enabling technology, software and people that can help build a seamless workflow to translate bench scale chemistry into a commercial process. For more than 20 years, our enabling tools and services have been a strategic resource providing critical information for thousands of development scientists and engineers. Companies have used that knowledge to accelerate the discovery, development and scale-up of new chemical processes spanning the chemical and biopharmaceutical industries. For more, visit http://www.mt.com.

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Patricia Hicks
METTLER TOLEDO
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