Researchers Report New Gene Therapy Slows Mesothelioma Growth in the Lab, According to Surviving Mesothelioma

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Japanese scientists say altering the proteins that direct blood vessel growth may offer a powerful new way to treat malignant mesothelioma.

Mesothelioma Growth Slowed with Proteins

Gene Therapy May Slow Mesothelioma Growth

Results like these appear to support the idea that gene therapy is an up-and-coming treatment approaches for mesothelioma...

Doctors with the Hyogo College of Medicine in Japan claim to have slowed the growth of mesothelioma cells in the lab by exposing them to anti-angiogenic proteins. Surviving Mesothelioma has just posted an article on the new research. Click here to read it now.

Using an altered virus to deliver the proteins, the researchers were able to alter the signaling proteins that are responsible for prompting blood vessel growth to feed a growing mesothelioma tumor. Without sufficient new blood vessel growth, a tumor cannot grow.

According to lead study author Shuji Kubo of the Hyogo College of Medicine, delivering a single anti-angiogenic protein to the mesothelioma cells “showed significant suppression of human umbilical endothelial cell growth in vitro compared with that of MSTO-C [the control].”

In addition, the study published in Oncology Reports found that using several signaling proteins together “significantly enhanced efficacy.”

“Results like these appear to support the idea that gene therapy is an up-and-coming treatment approaches for mesothelioma, a cancer that is highly resistant to conventional therapies,” says Surviving Mesothelioma’s Managing Editor, Alex Strauss.

Details of the new study, including which anti-angiogenic proteins were used to achieve these results, are available on the Surviving Mesothelioma website. Read Mesothelioma Cell Growth Slowed with New Gene Therapy.

Kubo, S, et al, “Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model”, June 12, 2015, Oncology Reports, Epub ahead of print,

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Cancer Monthy
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