BAP1+/- mice had a significantly higher incidence of mesothelioma after exposure to very low doses of asbestos...
(PRWEB) July 03, 2015
Scientists at several top US cancer centers believe they now know why certain people are more susceptible to mesothelioma with even minimal asbestos exposure. Click here to read the complete story, just posted on the Surviving Mesothelioma website.
Researchers at the University of Hawaii Cancer Center, Cedars Sinai Medical Center, and New York University exposed mice with a mutation on the tumor suppressor gene called BAP1 to small amounts of asbestos.
“BAP1+/- mice had a significantly higher incidence of mesothelioma after exposure to very low doses of asbestos, doses that rarely induced mesothelioma in wild-type [non-mutated] mice,” reports study author Andrea Napolitano, a graduate research assistant at the University of Hawaii Cancer Center.
The findings, published in the journal Oncogene, help explain why none of the mesothelioma patients they studied who had the BAP1 mutation had ever worked in a high-risk industry. The authors believe that a heightened inflammatory response at the cellular level may help explain the these peoples' higher sensitivity to the damaging effects of asbestos.
“Understanding who is at greatest risk for mesothelioma and why is a crucial first step on the road to potentially being able to prevent this devastating cancer, something medicine has not yet been able to do,” observes Alex Strauss, Managing Editor of Surviving Mesothelioma.
For a more in-depth look at the findings and their implications for present and future mesothelioma patients, see Even Minimal Asbestos Exposure May Trigger Mesothelioma in People with Gene Mutation, now available on the Surviving Mesothelioma website.
Napolitano, A, et al, “Minimal asbestos exposure in germline BAP1 heterozygous mice is associated with deregulated inflammatory response and increased risk of mesothelioma”, June 29, 2015, Oncogene, Epub ahead of print, http://www.nature.com/onc/journal/vaop/ncurrent/full/onc2015243a.html
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