New Research Suggests Mesothelioma May Not Strike Randomly, According to Surviving Mesothelioma

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Study finds possible “synergistic” effect between genes and asbestos may lead to higher mesothelioma risk.

Synergy Between Asbestos and Genes May Lead to Mesothelioma

Genetics May Influence Mesothelioma Development

Our results suggested that gene-asbestos interaction may play an additional role in malignant pleural mesothelioma susceptibility.

Italian researchers say certain genetic variations may explain why only 10 percent of people exposed to asbestos ever develop mesothelioma. Surviving Mesothelioma has posted a new article on the research. Click here to read it now.

Scientists at the University of Piemonte Orientale in Novara, Italy and other Italian medical centers analyzed the interaction between tiny genetic variations called Single Nucleotide Polymorphisms (SNPs) and asbestos, the only known cause of malignant mesothelioma.

“Our results suggested that gene-asbestos interaction may play an additional role in malignant pleural mesothelioma susceptibility,” writes lead author Dr. Sara Tunesi of the Unit of Medical Statistics and Cancer Epidemiology at the University of Piemonte Orientale.

The report in the journal Carcinogenesis reveals three specific SNPs that appear to be linked to greater sensitivity to the mesothelioma-triggering characteristics of asbestos.

“Although we have known for decades about the deadly effects of asbestos, the reason for the disparity between exposure and development has remained largely a mystery,” says Surviving Mesothelioma’s Managing Editor, Alex Strauss. “This study is an important step toward understanding who is most susceptible to mesothelioma and why.”

To read more about the study and its potential impact for present and future mesothelioma patients, see Mesothelioma Study Explores "Synergistic" Effect between Genes and Asbestos, now available on the Surviving Mesothelioma website.

Tunesi, S, et al, “Gene-asbestos interaction in malignant pleural mesothelioma susceptibility”, July 2, 2015, Carcinogenesis, Epub ahead of print,

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Cancer Monthy
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