Medicortex Finland Is Developing Diagnostic Tool Based on Biomarkers for Traumatic Brain Injury and Stroke

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Medicortex Finland Oy has started research to establish a biomarker and to develop a diagnostic test that would reliably establish the severity and extent of brain injury. Another mission for the company is to develop a pharmaceutical therapy which will limit the long-term effects of brain injury, including the types of severe brain trauma that may follow a stroke.

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In addition to everyone involved with modern traffic, athletes and sports professionals are amongst the people most likely to suffer a traumatic brain injury. Football players certainly aren't the only brain-injured sports figures in the news. The sporting world surely remembers Michael Schumacher, the German race car driver and Formula One winner, who suffered a near-fatal ski accident and a serious brain injury. No matter how much attention these stories receive, the real story of sports-related TBI lies in the sheer magnitude of the problem. It is estimated that TBI and Acquired Brain Injury (ABI) cause 9.6 million hospitalisations in Europe annually, with total costs in excess of €64 billion.

No reliable diagnostic tool exists for evaluating the extent and severity of brain injury. Medicortex is working towards the identification of a brain injury biomarker and incorporating it into a quick and accurate diagnostic kit that can be easily used by healthcare professionals. The ideal kit will not only diagnose the presence of a brain injury, it will also quantify its severity and indicate the treatment needed. In addition, the kit could become a key component of efficacy testing and an end point in all future clinical trials in TBI.

Numerous studies have found evidence that even one minor concussion can lead to long-term neurodegeneration. The symptoms of TBI occur as a result of repeated head trauma and include sleep disturbance, problems with concentration, nausea and seizures. When left untreated, these symptoms can develop into more severe neurodegenerative conditions, including Alzheimer’s and Parkinson’s. Many football players, boxers and hockey players suffer from memory problems, early-onset dementia, or even, in some rare cases, post-traumatic Parkinsonism.

Why, then, is TBI so insidious and so damaging? The answer lies in the cascade of physiological events that follow brain trauma. In the hours, days, and weeks following the injury, the increased permeability of the neuronal membrane allows for an excessive influx of metal ions and circulating free radicals which cause a series of protein degradation cascades and oxidation, leading to widespread molecular damage and neuronal cell death. In short, the damage expands if not treated after the initial trauma. Unfortunately for TBI sufferers, there are currently no treatments available. Not surprisingly, the medical community is well aware of the importance of early intervention in all forms and degrees of TBI. However, none of the currently available therapies really address TBI in the inclusive manner necessary to help reduce or even reverse damage already sustained.

Medicortex Finland is seeking investments to support the development of a diagnostic device and initial studies for assessing the biological activity and lack of toxicity of its pipeline compounds.

About Medicortex
Medicortex Finland Oy is a start-up pharmaceutical company dedicated to identifying biomarkers in order to reliably assess the severity and extent of brain injury. Medicortex Finland’s secondary mission is to develop new treatments for TBI and stroke. Medicortex was founded by Dr. Adrian Harel in 2014 in Turku, Finland, and operates as a privately owned company. Dr. Harel has a track record in leadership of early-stage drug discovery companies and business management.

Contact
Adrian Harel, Ph.D., MBA
Itäinen Pitkäkatu 4 B, 4th floor
FI-20520 Turku
Finland
Tel: +358 (0) 400 4888 17
Fax: +358 (0) 2251 0100
e-mail: adrian.harel(at)medicortex(dot)fi

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Adrian Harel
Medicortex Finland Oy,
+358 400488817
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