Improved Sensitivity to Chemotherapy?
For the first time, we show a role for autophagy in the response to chemotherapy of 3D models of mesothelioma.
Raleigh, NC (PRWEB) August 27, 2015
Doctors in the US, the UK and Switzerland say a drug called GDC-0980 might offer a new way to fight malignant mesothelioma – especially if given when cells are in the stage known as autophagy. Surviving Mesothelioma has just posted details of the new research. Click here to read the full article.
Cancer investigators with the University of California, the University of Zurich, Harvard Medical School and others manipulated the cell cycle stage in 3D models of mesothelioma to demonstrate an improved drug response.
“For the first time, we show a role for autophagy in the response to chemotherapy of 3D models of mesothelioma,” writes author Dario Barbone of San Francisco General Hospital, whose name appears first on the paper.
The study, published in the online open-access medical journal PLoS One, used 3D models of tumors from 21 mesothelioma patients.
“Lack of responsiveness to standard chemotherapy drugs is one of the things that makes mesothelioma so difficult to treat,” says Alex Strauss, Managing Editor for Surviving Mesothelioma. “If these results can be duplicated in larger studies, this new drug may offer hope to more patients.”
To read the details of the new study and its potential implications for mesothelioma patients, see Making Mesothelioma More Susceptible to Chemotherapy now available on the Surviving Mesothelioma website.
Barbone, D, et al, “Autophagy correlates with the therapeutic responsiveness of malignant pleural mesothelioma in 3D models”, August 18, 2015, PLoS One, http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0134825
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