InSphero Granted Hanging Drop Patent in United States

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Patent establishes protection of InSphero GravityPLUS™ technology in all major global markets, key milestone for leading provider of 3D cell culture platforms, microtissues and services.

The InSphero GravityPLUS™ Hanging Drop System enables more biologically relevant 3D cell culture.

We are excited the USPTO has recognized the originality of our design, and granted protection of the investment we have made into the creation of new technology. -- Dr. Jan Lichtenberg, InSphero AG CEO and co-founder.

The United States Patent and Trademark Office (USPTO) has officially granted InSphero AG full protection of its GravityPLUS™ hanging drop technology. InSphero, the world’s leading developer of easy-to-use solutions for organotypic 3D cell culture models and body-on-a-chip systems, now holds hanging drop patents in the world’s major pharmaceutical and biotechnology markets, including the United States, Europe, China, Japan, and Singapore. The core patent WO2010031194 describes multi-well plates which allow the generation of hanging drops for 3D cell culture, using convenient top loading of the cell suspension.

InSphero commercialized the hanging drop technology as the GravityPLUS™ Hanging Drop System in 2010. The system includes the GravityPLUS™ plate used for production of 3D spheroids in hanging drops, and also the companion GravityTRAP™ culture and assay plate, to which 3D microtissues are transferred for long-term culture and drug testing.

Dr. Jan Lichtenberg, CEO and co-founder of InSphero, says that the favorable decision has been a long time coming for InSphero. “We are excited the USPTO has recognized the originality of our design, and granted protection of the investment we have made into the creation of new technology. This protection allows us to operate unhindered in the US market, gives our customers the added confidence to invest in InSphero technology as their platform of choice for 3D cell culture, and provides the grounds necessary to defend against industry competitors attempting to imitate our technology.”

Granting of the patent on September 8 followed InSphero’s recent completion of a Series C financing round, and August announcement naming PerkinElmer as the exclusive global distributor of InSphero hanging drop and ultra-low attachment (ULA) plates for 3D cell culture.

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About InSphero

InSphero provides superior biological relevance to in vitro testing with its easy-to-use solutions for production, culture and assessment of more organotypic 3D cell culture models. The company’s patented 3D cell culture platforms and methods enable large-scale, reproducible production of a broad range of assay-ready 3D InSight™ Microtissues derived from liver, pancreas, tumor, heart, brain and skin. These models and contract research services utilizing them help to identify promising drugs and toxic liabilities with greater predictivity at early development stages, enabling better pre-clinical decision making, saving development cost, and shortening time to market. InSphero’s technologies drive significant findings in peer-reviewed journals, through collaborative projects such as EU Body on a Chip and HeCaToS, and validation in the world’s largest government institutions and pharmaceutical, chemical and cosmetics companies. This 3D know-how is now also being applied in the diagnostics field to aid development of personalized chemotherapeutic strategies for the treatment of cancer.

Founded in 2009, the privately held company is headquartered in Schlieren, Switzerland with subsidiaries in the United States (Brunswick, ME) and Waldshut, Germany. It has been recognized for its scientific and commercial achievements with a number of national and international awards.

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Randy Strube
InSphero AG
+1 800-779-7558 Ext: 102
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Jan Lichtenberg
InSphero AG
+41 44 515 0490
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