Announces Research IQBots For Quantative Analysis Of Muscle Imaging Data

Share Article

IQbot specifically for heart and skeletal muscle fiber analysis (reticulin stain), an automated platform for quantitative preclinical imaging analysis and data aggregation created by ImageIQ, today announced the addition of two new IQbots that eliminate the obstacles associated with manual analysis of the muscle imaging data: The Heart Muscle Fiber Analysis (Reticulin Stain), and Skeletal Muscle Fiber Analysis (Reticulin Stain). “IQbots” are the engines that power the analysis and management workflow — online tool packages for common or custom preclinical imaging assays that deliver validated, comprehensive analytics that are objective, reproducible, and accessible. Within every IQbot results package researchers receive complete data (i.e., quantitative excel spreadsheets, image analysis overlays, usable file formats), individual image validation certification, and reference materials (e.g., a video walkthrough of output data, relevant references from scientific literature, methods sections, material to support GLP compliance, and a validation certificate).

Each of these IQbots acts in their indicated context to analyze muscle fiber content and morphology in histological cross-sections of tissue stained for reticulin, a connective fiber composed of type III collagen. A number of metabolic and cardiovascular disorders can affect muscle fiber density, size, and shape. Unfortunately, such phenotypic effects can be subtle, necessitating the quantification of morphological parameters for as many muscle fibers as possible within a given imaged cross-section for a large cohort of samples — an exhaustive process if performed manually. Fortunately, the muscle fiber analysis IQbots were specifically designed to rapidly and comprehensively segment muscle fibers (in cross-section) within an image, extracting fibril number, area, aspect-ratio or elongation, roundness or roughness, perimeter, and diameter. These can be presented as averages or, using an advanced version of the IQbot, can be reported for each and every fibril segmented. Additionally, segmented fibrils are pseudo-colored red and superimposed upon each image analyzed to enable verification of the results and segmentation algorithm.

This IQbot will join the existing catalog in assisting users to more effectively (in terms of the quality standard of the data) and more efficiently (in terms of cost and time-to-analysis) arrive at the imaging analytics required of their research. As with all prior offerings, the Heart and Skeletal Muscle Fiber Analysis IQbots were developed and released following a rigorous validation process that stressed the accuracy and reproducibility of the produced data. software engineers are consistently building new IQbots to add to the processing catalog. To prompt prioritization of an IQbot for their own analysis needs, researchers may submit requests to enter the “IQbot Incubation Program.” Researchers submitting requests will receive a notification within 10 business days identifying whether or not their assay has been chosen for development. Such decisions rely on estimates as to the time and technical resources required to develop and validate the IQbot, as well as the relative industry need.

Share article on social media or email:

View article via:

Pdf Print

Contact Author

Brett Hoover
+1 8554624347
Email >
Visit website