Report Finds Corticosteroids Can Help Prevent Mesothelioma Chemotherapy Rash

Share Article

New evidence suggests that taking small amounts of corticosteroids for the first three days of chemotherapy treatment may help mesothelioma patients avoid an uncomfortable skin rash.

Steroids May Help Ward Off Chemotherapy Rash

Treating Rash in Mesothelioma Patients

Administration of ≥1.5 mg of corticosteroids on day 2 and day 3 significantly reduced the severity of the rash compared to no supplementary treatment.

Japanese doctors say mesothelioma patients who are treated with a corticosteroid drug like dexamethasone while on chemotherapy with pemetrexed are less likely to develop a serious skin rash. Surviving Mesothelioma has just posted an article on the new research. Click here to read it now.

Doctors at Tokushima University compared the cases of 78 mesothelioma patients on the common chemotherapy drug, pemetrexed. Many of those who had dexamethasone during the first three days of treatment avoided one of pemetrexed’s unpleasant but common side effects.

“Administration of ≥1.5 mg of corticosteroids on day 2 and day 3 significantly reduced the severity of the rash compared to no supplementary treatment. However, increasing the dose of corticosteroids had no additional effect on rash development,” writes author Takumi Sakurada, PhD.

The authors of the report in Biological and Pharmacological Bulletin say that, while corticosteroids have been used to treat pemetrexed-induced rash in mesothelioma patients, their use and dosing had not been fully verified.

“Chemotherapy for mesothelioma is difficult enough without patients also having to deal with the discomfort of a skin rash,” says Alex Strauss, Managing Editor of Surviving Mesothelioma. “We are hopeful that this new information may help improve the clinical management of rash in mesothelioma patients who are or will be on pemetrexed.”

For a more thorough explanation of the study findings and to learn more about chemotherapy for mesothelioma, see Mesothelioma Patients May Avoid Chemotherapy Rash with This Medicine, available now on the Surviving Mesothelioma website.

Sakurada, T et al, “Pemetrexed-Induced Rash May Be Prevented by Supplementary Corticosteroids”, 2015, Biological and Pharmacological Bulletin, pp. 1752-1756. http://www.ncbi.nlm.nih.gov/pubmed/26521826

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

Share article on social media or email:

View article via:

Pdf Print

Contact Author

Michael Ellis
Cancer Monthy
+1 (919) 570-8595
Email >
Follow us on
Visit website