We the People and Synaptic Serotonin (5-HT) Science ~ A New Update on the Bryan William Brickner Blog

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We the People and our synaptic serotonin systems are the focus found in four 2015 (short) science tales from the National Institutes of Health (PubMed). In today’s update, author Bryan W. Brickner highlights the new serotonin (5-HT, 5-hydroxytryptamine) research on OCD, brains, and suicide solutions.

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With suicide and the serotonin transporter, SERT, the science shows only a small genetic association while pointing out the politically obvious: the serotonin system is part of every suicide solution.

“We the People is a higher thought,” opened Bryan W. Brickner, “and the serotonin system is fundamental to all thoughts.”

In We the People and Synaptic Serotonin (5-HT) Science, a new update on the Bryan William Brickner Blog, the focus is serotonergic homeostasis, with particular attention on the central nervous system. In January, Brickner published Shivitti: A Review of Ka-Tzetnik 135633’s Vision, a serotonin system (lysergic acid, LSD) book review on healing Auschwitz nightmares. Today’s post continues the serotonin and healing – for all people – storyline with new 2015 science from the National Institutes of Health (PubMed), which highlights: selective serotonin reuptake inhibitors (SSRIs) and obsessive-compulsive disorder (OCD), 5-HT3 receptors and OCD, prefrontal cortex (brain) and 5-HT2A receptors, and genetic research on suicide and the serotonin transporter gene (5-HTT, SERT).

“There are two today on OCD,” explained Brickner, “with one on the robust data supporting the effectiveness of treatment with selective serotonin reuptake inhibitors (SSRIs), the acknowledged first-line pharmacological treatment of choice.”

“The second OCD serotonin report is scanty,” Brickner continued, “as the research is hampered by a lack of data; the scientific interest is in the serotonin 5-HT3 receptor and OCD patients – though a PubMed review only turned up six publications on the topic, not enough to draw valid conclusions.”

“For the brain serotonin science,” noted Brickner, “research shows the 5-HT2A receptors in the prefrontal cortex regulating dopamine release; this stimulates a ‘long-loop’ feedback system from the cortex to other parts of the brain … and back.”

“With suicide and the serotonin transporter, SERT,” Brickner closed, “the science shows only a small genetic association while pointing out the politically obvious: the serotonin system is part of every suicide solution.”

Brickner has a 1997 political science doctorate from Purdue University and is the author of several political theory books, to include: The Promise Keepers: Politics and Promises (1999), Article the first of the Bill of Rights (2006), and Shivitti: A Review of Ka-Tzetnik 135633’s Vision (2015). He also writes political fiction, such as the novella thereafter (2013), and is the publisher of The Cannabis Papers: A citizen’s guide to cannabinoids (2011) and The Bryan William Brickner Blog, a resource for the political science of constitutions and the biological science of receptors.

Next Ew Publishing: Tomorrow, Sunday 22 February, We the People, Publius and Homeostatic Cannabinoids.

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