Human Trial Supports the Detoxification Action of Spanish Black Radish

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Trial was performed using Standard Process Inc.’s Spanish Black Radish supplement.*

A recently published human trial supports the detoxification action of Standard Process’ Spanish Black Radish supplement.

This approach brought positive results in support of Spanish Black Radish positively influencing the clearance of acetaminophen.

Spanish Black Radish, a supplement from Standard Process Inc., can induce the body’s detoxification enzymes as measured by subsequent metabolites and support the body’s normal toxin elimination function, according to a human trial published December 9, 2014.

Cruciferous vegetables, like Spanish black radish, contain unique bioactive compounds that increase the gene expression of phase one and two enzymes. These enzymes break down some chemicals so the body can safely remove them.

David Barnes, Ph.D., MBA, an author on the paper and former director of research and development at Standard Process says, “I am excited about this publication. It represents the culmination of many years of work on Spanish black radish. We developed a firm understanding of the ingredient’s potential to support health and have finally validated our information in humans.”

The paper, “An open label pilot study to evaluate the efficacy of Spanish black radish on the induction of phase I and phase II enzymes in healthy male subjects,” published in BMC Complementary and Alternative Medicine, followed 20 healthy, male subjects over the course of four weeks. At the beginning of the trial and after four weeks the subjects were given 1,000 milligrams of acetaminophen. The study compared the rate at which acetaminophen was processed before and after consumption of the supplement. The study used acetaminophen as a model compound because it is metabolized by the liver though detoxification pathways that are effected by phase one and two enzymes.

"This study took a unique approach by looking at the mechanism of action of a dietary supplement in the liver metabolism of acetaminophen," said Dr. Malkanthi Evans, D.V.M., Ph.D., M.Sc., lead author and scientific director of KGK Synergize Inc., the company that performed the study. "This approach brought positive results in support of Spanish Black Radish positively influencing the clearance of acetaminophen. By way of this, we have also brought a valuable study design to the table for future clinical research on clearance models and supplementation."

Compared to baseline, phase two enzyme products in plasma decreased and urinary phase two enzyme products increased after four weeks of consuming Spanish Black Radish. This indicates increased acetaminophen elimination and suggests the phase two enzymes responsible for these metabolites were up-regulated.

To determine if phase one enzymes were also up-regulated, the authors measured serum 17β-estradiol, a hormone that is present at very low levels in men. When compared to baseline, the amount of 17β-estradiol in serum at week four decreased, suggesting that phase one enzymes were indeed up-regulated by consumption of the supplement.

Phase one and phase two enzymes work together to help the body breakdown and manage compounds that need to be removed. It is important to have a balanced reaction in order to maintain the body’s normal detoxification processes.

This research confirms that Spanish Black Radish can contribute to the body’s normal, balanced phase one and phase two detoxification processes and assist in elimination of natural toxins from the body.

“I am very happy to finally have these important findings out in the public domain,” said Sara Arscott, Ph.D., C.C.R.P., manager of clinical research at Standard Process. “We remain committed to conducting quality clinical trials through private and public collaborative partners with the goal of demonstrating the efficacy of our product line and supporting the health of patients.”

In 1981, Standard Process introduced Spanish Black Radish, a supplement containing organically grown Spanish black radish from the company’s organic farm in Palmyra, Wisconsin and processed to safeguard its nutritional value. This supplement provides support for the body’s organs, supports healthy liver and gallbladder function, and induces the body’s detoxification enzymes.* Standard Process researchers have shown in cell culture, mice and now humans that this ingredient and supplement can support the body’s normal toxin elimination function.

To learn more about research and development going on at Standard Process, visit the Research and Development page at

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.


About Standard Process Inc.

For more than 85 years, Standard Process has been dedicated to the field of nutritional supplements and the whole food philosophy introduced by its founder, Dr. Royal Lee. Standard Process, headquartered in Palmyra, Wis., offers more than 300 high-quality supplements with whole food ingredients through three product lines: Standard Process and Standard Process Veterinary Formulas supplements, and MediHerb herbal supplements. The products are available only through health care professionals.

To ensure its supplements are of the utmost quality, Standard Process grows the majority of its ingredients on company-owned, organically certified farmland. The company uses exclusive manufacturing processes to retain vital nutrients within each ingredient and employs high quality control standards, including adhering to the Food and Drug Administration’s good manufacturing practice requirements.

Standard Process employs more than 330 people. The company is a recipient of the Platinum Well Workplace Award from the Wellness Councils of America and has distinguished itself as a leader and innovator in workplace health promotion. In 2014, Standard Process launched Cultivate by Standard Process, a business that delivers scalable wellness solutions to impact individual employees and the overall company using onsite chiropractic as a central component of the program.

Standard Process is also distinguished as an exemplary environmental citizen. The company is a Tier I participant in the Wisconsin Department of Natural Resources’ Green Tier program, which recognizes companies with strong environmental compliance records. For additional information about Standard Process, visit

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Karren Jeske, APR
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