One Million Solutions in Health’s Technology Evaluation Consortium™ Evaluated the Organovo 3D Human Liver Tissue Model as Innovator in Its Signature Square™

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The designation of Innovator was bestowed upon Organovo’s 3D human liver tissue model via the One Million Solutions in Health Signature Square™ program after an evaluation by members of the Technology Evaluation Consortium.

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The designation of Innovator was bestowed upon Organovo’s 3D human liver tissue model via the One Million Solutions in Health Signature Square™ program after an evaluation by members of the Technology Evaluation Consortium.

The One Million Solutions in Health™ Technology Evaluation Consortium™ designated this Organovo 3D Human Liver Tissue Model as Innovator technology through its Signature Square™ program. This innovative technology from Organovo Holdings Inc. in San Diego, California, is a 3D human liver tissue model which allows pharmaceutical companies to determine the effects of their drugs on the human liver, simulating in vivo conditions.

The Signature Square program provides feedback to technology or service providers (commercial, academic, government, healthcare institutions, etc.) based on confidential reviews by Subject Matter Experts in the life sciences and health care sectors for new or established solutions.

The consortium members independently chose to review this technology and evaluate its role and usefulness in drug safety. Based on their analysis and ratings, the consortium members provided a designation for this solution: Organovo 3D Human Liver Tissue Model as Innovator.

Organovo’s new technology was developed in order to combat the fact that hepatocytes replicate poorly, and rapidly lose critical liver-specific functions once removed from the body. Hepatocytes inside the body are polarized along a border of endothelial cells, with formation of canaliculi along their apical surface and tight junctions between neighboring cells.

Loss of polarization, such as when hepatocytes are removed from the body, leads to loss of function and an inability of the hepatocyte to maintain the intracellular architecture that enables absorption, transport and bile production. It is known from the literature that hepatocytes which are maintained in culture environments that support polarization and three-dimensionality, retain critical functions for a longer period outside of the body. The bio-printing platform used by Organovo allows fabrication and comparative testing of multiple compositions and geometries so that the optimal combination of the aforementioned aspects can be found. This process occurs based on histological and functional outcomes.

“One Million Solutions in Health is pleased to bring Organovo’s new technology to the Technology Evaluation Consortium,” stated Dawn Van Dam, President and CEO of One Million Solutions in Health. “By collaborating with the experts in the field, the Signature Square program accelerates the consideration, development and optimization of innovative scientific technology.”

All technologies rated through the Signature Square process are given a designation in one of the four potential technology or service categories: Blockbuster, Novel, Upstart or Innovator. The rating for this patented Organovo 3D Human Liver Tissue Model as Innovator was provided via the evaluation by Subject Matter Experts from around the world. The Signature Square evaluation occurs on two dimensions: 1) Value Proposition to the Marketplace and 2) Market or Partner Readiness.

A One Million Solutions in Health Signature Square evaluation uses a combination of quantitative research, numerical scoring and respondents’ comments, or qualitative feedback, as it reflects the offering’s differentiated position in the market. By focusing on end-user feedback, and applying a graphical treatment and a uniform set of evaluation criteria, a Signature Square helps research teams quickly ascertain how well a technology or service is positioned to provide value to the market and how ready it is to provide that value.

The Signature Square is an opportunity for technology or service providers to receive direct evaluations and feedback which can then be used to inform potential investors, end users and/or partners. It can also be utilized as a component towards understanding the technology or service and its potential to contribute to health care.

The Subject Matter Experts are members of the Technology Evaluation Consortium with specific expertise in the relevant area for each technology, including individuals from top biopharmaceutical, diagnostic, device, health data or healthcare organizations in the field, as relevant. One Million Solutions in Health aims to have a broad representation of feedback and advice from relevant Subject Matter Experts in each area. These experts evaluate the technology or service such that the feedback received is valid and valuable.

The positioning within the Signature Square is related to the aforementioned criteria, along with the point-in-time at which it has been evaluated. Consequently, a technology evaluated early could be considered an Innovator, but by addressing the feedback received in the process, could eventually be considered a Blockbuster.

For an opportunity to join the Technology Evaluation Consortium, and review the detailed information, video and evaluation for this technology: Organovo 3D Human Liver Tissue Model as Innovator, please contact Dawn Van Dam at One Million Solutions in Health (dawn.vandam(at)

About One Million Solutions in Health

The goal of One Million Solutions in Health™ is to shape health care by sharing solutions and, importantly, to accelerate the discovery, development and delivery ... of innovative cures, treatments and preventative measures for patients around the world.

In this next year, we will be reviewing 1000's of new solutions and new scientific discoveries. By engaging scientists, entrepreneurs, investors, innovators, industry experts, health care professionals, and patients across various disciplines, and from around the world, we can utilize the power of the internet to disrupt things in a positive and transformative way to accelerate the movement of new solutions and scientific discoveries from the scientist to the patient.

We are on our way towards accelerating high-potential innovations, catalyzing investment and increasing awareness of, and support for, transformative ideas to improve health and save lives. By facilitating efforts to ensure organizations can Connect, Learn + Share, Innovate and Collaborate, our vision is to improve health care delivery, accelerate life sciences research and share patient and consumer-focused ideas and solutions.

As a not-for-profit, we welcome your participation and are thrilled to have you be a part of this transformative journey!

About The Technology Evaluation Consortium

The Technology Evaluation Consortium™ from One Million Solutions in Health™ is dedicated to improving and accelerating life sciences R&D and health care outcomes. The Technology Evaluation Consortium brings together life sciences and/or health care companies and industry vendors or scientists, and other relevant partners (e.g., government and Universities), to evaluate and validate technologies or services in a collaborative environment.

The model empowers technology providers/scientists and industry end-users to collectively assess a number of solutions in a cost-effective manner, producing a depth and breadth of results that no company can achieve alone. Our mission is to triage and streamline new technology consideration for the industry and to be the place for the industry to conduct their evaluations and validations.

Media Contact:
Dawn Van Dam
President and CEO

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Dawn Van Dam
since: 04/2012
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