Claremont BioSolutions’ Novel Sample Preparation Devices and Reagents Deployed in NASA’s Wetlab-2 Project Arrive to International Space Station

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NASA's WetLab-2 Sample Preparation Module (SPM) utilizing ClaremontBio’s rapid lysis and RNA isolation technologies set to perform sample prep for gene expression studies on the ISS.

WetLab-2 fluidics engineer Travis Boone instructs NASA astronaut Jeff Williams on the operation of WetLab-2 hardware during a crew training session at NASA’s Johnson Space Center. Credits: NASA / Bill

"Claremont BioSolutions is excited and honored to be part of the WetLab-2 project. Our core devices are well suited for applications that require low power, compact size, and ease-of-use." Dr. Robert Doebler, ClaremontBio's President & co-founder

Claremont BioSolutions, LLC, an innovator of rapid and easy-to-use sample preparation devices, announced today that components of its SimplePrep™ technology recently arrived on board the International Space Station (ISS) as part of the NASA Ames Research Center’s WetLab-2 project which was successfully delivered to the ISS on Sunday morning aboard the SpaceX Dragon capsule.

While on board the ISS, the WetLab-2 Sample Prep Module (SPM) will be used as a research tool to help study how spaceflight affects gene expression in microbes and mammalian cells to shed light on molecular and cellular mechanisms in microgravity environments. Integrated in the heart of the SPM are customized components of ClaremontBio’s SimplePrep™ technology (OmniLyse®, microHomogenizer™, and RNAexpress™ devices with associated reagents), that will perform all-in-one lysis of bacteria, yeast, and mammalian cells and isolate total RNA for downstream analysis.

During the development of the SPM, ClaremontBio worked with the WetLab-2 team to adapt the components for use in the fully enclosed module. As part of NASA’s flight qualifications, ClaremontBio’s technology was rigorously tested for over two years, including efficiency and reproducibility tests in non-orbital, in-flight microgravity conditions.

ClaremontBio’s President and co-founder, Dr. Robert Doebler said “Claremont BioSolutions is excited and honored to be part of the WetLab-2 project. Our core devices are well suited for applications that require low power, compact size, and ease-of-use. WetLab-2’s Sample Prep Module will provide a unique validation of our technology.” He went on to say, “Collaborations such as this demonstrate the ability of ClaremontBio’s interdisciplinary team of scientists and engineers to address needs in challenging areas of biological research. We appreciate the opportunity to collaborate with a talented team of similar-minded professionals at NASA Ames.”

In addition to integration of the SimplePrep™ technology in the SPM, ClaremontBio has expanded its sample prep product line by completing development of its automated SimplePrep™ X8 and X1 portable instruments that allow hands-free cell lysis and nucleic acid extraction of up to eight samples of tough-walled microorganisms in difficult sample matrices within six minutes.

About Claremont BioSolutions, LLC.
Claremont BioSolutions (http://www.ClaremontBio.com) is a privately held, emerging growth technology company specializing in miniaturized, disposable devices, as well as automated multiplexed instruments, that provide solutions to what is recognized as the “bottleneck” of nucleic acid diagnostics – sample preparation. The company has developed proprietary disposable devices that employ micromotors capable of performing very rapid and efficient mechanical tissue homogenization, cell lysis, and nucleic acid extraction.

Contact:
Robert Doebler, Ph.D.
President and co-founder
Claremont BioSolutions, LLC
E‐Mail: rdoebler(at)claremontbio.com
Phone: (909) 920-3887
Fax: (909) 946‐1132
Address: 1182 Monte Vista, Ave., Suite 11
Upland, CA. 91786

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John Maveety
@ClaremontBio
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