New Research Reveals DNA Mutations Underlying Mesothelioma, According to Surviving Mesothelioma

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Scientists say Next Generation Sequencing may lead to better diagnostic tools and more targeted mesothelioma therapies.

The Genetics Behind Mesothelioma

NGS Sequencing for Mesothelioma

These findings will help in the development of new screening tools and targeting therapies...

The Mayo Clinic has released new data on some of the specific genetic mutations that may give rise to many cases of pleural or peritoneal mesothelioma. Surviving Mesothelioma has just posted an article on the new research. Click here to read it now.

Researchers used NGS or "high-throughput" technology to screen for 236 cancer-related mutations in the genes of 11 mesothelioma patients.

“These findings will help in the development of new screening tools and targeting therapies, and in turn impact the standard-of-care and potentially lengthen disease control and survival periods in the future,” writes lead author Dr. Gamze Ugurluer.

The study, published in Anticancer Research, revealed three gene “families” that were the most frequently mutated genes among the mesothelioma patients studied.

“Current cancer therapies have limited success in treating mesothelioma. Therapies that target specific genetic mutations have the potential to finally turn the tide of this deadly cancer,” says Alex Strauss, Managing Editor of Surviving Mesothelioma.

For more on the new Mayo Clinic study, including which genetic mutations are most common among mesothelioma patients, see Genome Sequencing in Mesothelioma: The Key to a Cure? now available on the Surviving Mesothelioma website.

Ugurluer, G, “Genome-based Mutational Analysis by Next Generation Sequencing in Patients with Malignant Pleural and Peritoneal Mesothelioma”, May 2016, pp. 2331-2338,

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Michael Ellis
Cancer Monthy
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