UAS LifeSciences: Study Confirms Benefits of Probiotics and Cranberry Combination for Urinary Tract Health

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Discovery may lead to fewer urinary tract issues

UP4 Women's Probiotic
The results of the study are very promising and confirm the synergy of the active ingredients. We are looking forward to moving on to human trials.

It’s a problem known all too well by many women. That awful feeling of realizing you are having urinary tract issues. In fact, one in five women will experience urinary tract issues during their lifetime, and the bacteria that causes them is 10 times more common in women than men. Now, the results of an in vitro (conducted outside of a living organism) clinical trial, published in the August 2016 edition of the Journal of Functional Foods, may be able to provide some relief as well as answers. Results of the study indicated that the combination of whole organic cranberry powder and specific probiotic strains may actually aid in supporting urinary tract health.     

The study was conducted by UAS LifeSciences, manufacturer of UP4 Probiotics, and Fruit d'Or Nutraceuticals, manufacturer of Cran Naturelle. It was performed with the collaboration of Complete Phytochemical Solutions and the Reed Research Group at the University of Wisconsin-Madison, both well-known for their knowledge of plant bioactives.

“We are honored to have partnered with those at UW-Madison that specifically have expertise with cranberry proanthocyanidins (PACs), the active ingredient in cranberries for supporting urinary tract health,” states Dr. Greg Leyer, Chief Scientific Officer of UAS LifeSciences as well as one of the study’s authors. He adds, “The results of the study are very promising and confirm the synergy of the active ingredients. We are looking forward to moving on to human trials.”

The product studied was UP4 Women’s, a part of UAS LifeSciences’s line of award-winning probiotic supplements. It contains a mix of robust, acid and bile resistant probiotic strains found naturally in a healthy vaginal cavity (including their trademarked superstrain Lactobacillus acidophilus DDS-1) in addition to whole organic Cran Naturelle cranberry powder.

“Cran Naturelle was selected as the cranberry powder used in this formulation because of its superior quality. There is no other cranberry powder available with a higher concentration of PACs,” states Stephen Lukawski, Director of Sales and Business Development for Fruit d'Or, manufacturer of Cran Naturelle.

Based on this positive outcome, gold standard, double-blind, placebo-controlled human trials are planned.

You can find UP4 Probiotics at Target stores nationwide along with fine health food stores including The Vitamin Shoppe, Whole Foods, and Sprouts Farmers Market.

The complete study can be viewed on the Journal of Functional Foods website:

Polewski, MA, Krueger, CG, Reed, JD, and G. Leyer. 2016. Ability of cranberry proanthocyanidins in combination with a probiotic formulation to inhibit in vitro invasion of gut epithelial cells by extra-intestinal pathogenic E. coli. J. Functional Foods. 25: 123-134.

About UAS LifeSciences
Founded in 1979, UAS LifeSciences, has delivered the highest quality, science-backed probiotics to the wellness products marketplace for more than thirty-five years. Strictly dedicated to probiotic-based supplements, UAS LifeSciences is committed to designing innovative and effective formulations including Lactobacillus acidophilus DDS®-1, one of the few probiotic strains researched to be beneficial in all age groups, and the patented Lactobacillus reuteri NCIMB 30242 (LRC™), the first strain clinically studied for supporting healthy cholesterol levels. The company is fully integrated from formulation through manufacturing, from packaging through marketing and distribution and adheres to the highest quality standards. To learn more, visit

About Fruit d'Or
Fruit d'Or Nutraceuticals is a global leader in organic processing and supply of nutraceutical cranberry and blueberry powders. The company positions itself as a next generation partner in advanced cranberry by providing cutting-edge innovation in technology and science. Fruit d'Or Nutraceuticals engages in product development, research and a commitment to quality and safety to distinguish itself from the competition. The company controls the quality from the seed to the field, from harvest to manufacturing to retail. This one-stop Canadian facility provides non-GMO, organic, state-of-the-art quality control, and traceability, key factors to its and the industry's future growth and long-term success. Explore    

2014. Urinary tract infection in women.
2010. Urinary Tract Infections.

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Mariah Saerndahl
since: 08/2013
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