New Research Highlights Value of Tumor Grading in Mesothelioma Prognosis, According to Surviving Mesothelioma

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A team of pathologists from top cancer centers say tumor grade correlates with peritoneal mesothelioma survival.

Nuclear Grade and Mesothelioma Prognosis

Tumor Grade and Mesothelioma Survival

The low-grade tier had higher overall [mesothelioma] survival...when compared with the high-grade tier...

A new study on the relationship between tumor grade and prognosis suggests that the level of abnormality seen in the nuclei of tumor cells under the microscope is related to mesothelioma outcomes. Surviving Mesothelioma has just posted an article on the new research. Click here to read it now.

Doctors at Wake Forest Baptist Health, the University of Mississippi Medical Center, and Memorial Sloan Kettering Cancer Center examined the pathological findings from 46 peritoneal mesothelioma cases. They found that those with a higher tumor grade (greater nuclear abnormality) had the worst odds of mesothelioma survival.

“The low-grade tier had higher overall survival with a median of 11.9 years and 57% at 5 years when compared with the high-grade tier with a median of 3.3 years and 21% at 5 years (P=0.002),” writes study author Kari Valente, MD, with Wake Forest Baptist Health in North Carolina.

The findings of this study, published in the American Journal of Surgical Pathology, were similar to the findings of an earlier study on tumor grade and pleural mesothelioma.

“Although tumor grade has been associated with pleural mesothelioma prognosis, this is the first study to link it to peritoneal mesothelioma outcomes, as well,” says Surviving Mesothelioma Managing Editor, Alex Strauss.

Details of the new study and an explanation of tumor grade, including how it differs from tumor stage, can be found in Tumor Grade Helps Predict Peritoneal Mesothelioma Survival, now available on the Surviving Mesothelioma website.

Valente, K, et al, “A Histomorphologic Grading System That Predicts Overall Survival in Diffuse Malignant Peritoneal Mesothelioma With Epithelioid Subtype”, July 19, 2016, American Journal of Surgical Pathology, Epub ahead of print,

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Michael Ellis
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