These markers may improve clinical and pathological practice, finally leading to a patient’s benefit...
Raleigh, NC (PRWEB) October 06, 2016
Researchers in Germany and Greece have just released new research suggesting a powerful role for genetic markers called microRNAs in refining treatment for malignant mesothelioma. Surviving Mesothelioma has just posted an article on the new research. Click here to read it now.
Scientists with the University of Duisburg-Essen in Essen, Germany and Theagenio Cancer Hospital and the University of Athens in Greece tested 24 mesothelioma tumor specimens for expression of 366 different microRNAs, genetic material responsible for producing vital proteins.
The teams found that expression of certain genes correlated with mesothelioma stage, metastasis, treatment responsiveness, and overall mesothelioma survival.
“After a prospective validation, these markers may improve clinical and pathological practice, finally leading to a patient’s benefit by an enhanced clinical management,” writes first author Dr. Robert Fred Henry Walter of the University of Duisburg-Essen.
Among mesothelioma patients who had received chemotherapy, the researchers found certain genetic expressions that were “significantly associated” with overall mesothelioma survival.
“Scientists still do not know why even the best chemotherapy for mesothelioma is only marginally effective,” says Alex Strauss, Managing Editor of Surviving Mesothelioma. “This study suggests that the answer is likely to lie in a patient’s genes and that genetic screening has the potential to help more patients survive mesothelioma.”
For a complete explanation of the new study and lists of genes that appear to impact mesothelioma treatment, see DNA Screening May Enhance Mesothelioma Treatment, now available on the Surviving Mesothelioma website.
Walter, RF, et al, “Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy.” September 13, 2016, Journal of Cancer, pp. 1915 - 1925. http://jcancer.org/v07p1915
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