New Study Suggests DNA Damage Markers Could Point to Better Mesothelioma Treatments, According to Surviving Mesothelioma

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Scientists now say gene expression that indicates DNA damage could be used to create more powerful and targeted therapies for pleural mesothelioma.

Mesothelioma Outcomes Linked to Gene Expression

Gene Expression and Mesothelioma Treatment

These markers may improve clinical and pathological practice, finally leading to a patient’s benefit...

Researchers in Germany and Greece have just released new research suggesting a powerful role for genetic markers called microRNAs in refining treatment for malignant mesothelioma. Surviving Mesothelioma has just posted an article on the new research. Click here to read it now.

Scientists with the University of Duisburg-Essen in Essen, Germany and Theagenio Cancer Hospital and the University of Athens in Greece tested 24 mesothelioma tumor specimens for expression of 366 different microRNAs, genetic material responsible for producing vital proteins.

The teams found that expression of certain genes correlated with mesothelioma stage, metastasis, treatment responsiveness, and overall mesothelioma survival.

“After a prospective validation, these markers may improve clinical and pathological practice, finally leading to a patient’s benefit by an enhanced clinical management,” writes first author Dr. Robert Fred Henry Walter of the University of Duisburg-Essen.

Among mesothelioma patients who had received chemotherapy, the researchers found certain genetic expressions that were “significantly associated” with overall mesothelioma survival.

“Scientists still do not know why even the best chemotherapy for mesothelioma is only marginally effective,” says Alex Strauss, Managing Editor of Surviving Mesothelioma. “This study suggests that the answer is likely to lie in a patient’s genes and that genetic screening has the potential to help more patients survive mesothelioma.”

For a complete explanation of the new study and lists of genes that appear to impact mesothelioma treatment, see DNA Screening May Enhance Mesothelioma Treatment, now available on the Surviving Mesothelioma website.

Walter, RF, et al, “Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy.” September 13, 2016, Journal of Cancer, pp. 1915 - 1925.

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Cancer Monthy
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