F-star Selects Genedata Biologics for Immuno-Oncology Therapeutics Discovery

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Genedata Biologics™ implemented as an integrated workflow platform to increase throughput and automation of F-star’s bispecific discovery operations

Genedata Biologics Antibody Developability Assessment

Traffic-light system for developability assessment based on individually reported quantitative and qualitative results

We believe Genedata Biologics will help us to accelerate the discovery of the next generation of immuno-oncology therapeutics

Genedata, a leading provider of advanced software solutions for drug discovery and life science research, today announced that F-star has licensed Genedata Biologics™ for use in their antibody discovery programmes. The platform will be used to increase the throughput of F-star’s bispecific antibody (mAb² ™) discovery operations from early screening and lead identification, to expression, purification, analytics and manufacturability assessment.

“We are excited that F-star, a leader in the discovery and development of novel bispecific antibodies, has joined the growing number of companies that use the Genedata Biologics platform. This is another example of how highly innovative companies like F-star can benefit from a platform that systematically processes, manages, and analyses complex biopharma R&D data and ultimately helps to design and engineer superior therapeutics,” said Dr. Othmar Pfannes, Chief Executive Officer of Genedata. “We continue to invest into growing our products to address new and future needs of drivers of innovation such as F-star.”

Genedata Biologics will help increase the experimental throughput of F-star’s proprietary technology platform, which is used to introduce a novel antigen-binding site into the constant (Fc) region of an antibody. The resulting molecule (called Fcab™) can rapidly be inserted into any existing antibody to generate a full-length mAb². Genedata Biologics will provide an integrated assessment of bioactivity, developability, and manufacturability for all such drug candidates.

“F-star develops innovative, targeted immunotherapies to fight cancer through several mechanisms. We have been looking for a workflow system that enables us to scale-up the throughput of our discovery programmes and addresses the large number of bispecific antibodies generated through our proprietary technology platform. We evaluated the market and quickly came to the conclusion that Genedata Biologics would suit our needs,” said Dr. Neil Brewis, CSO of F-star. “Genedata Biologics provides a flexible architecture and includes built-in biopharma domain knowledge, which can handle our proprietary bispecific antibody discovery processes. We believe Genedata Biologics will help us to accelerate the discovery of the next generation of immuno-oncology therapeutics.”

In the five short years since its first release in 2011, Genedata Biologics has been rapidly adopted by half of the world’s leading biopharmaceutical companies. Genedata’s collaborations range from single group installations to large, global, multi-site partnerships and include technology transfer, customizations, project management, training, and roll out and deployment support.

About Genedata
Genedata transforms life science data into intelligence with a portfolio of advanced software solutions and scientific consulting. With award-winning platforms, combined with deep domain expertise, Genedata enables dramatic increases in productivity and quality of research, development, and production. Founded in 1997, Genedata is headquartered in Switzerland and has offices in Germany, Japan, and the US.
http://www.genedata.com
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About F-star
F-star is a clinical stage biopharmaceutical company developing bispecific antibody immuno-oncology products selected for their potential to transform the treatment of cancer. Through the application of its highly efficient Modular Antibody Technology™ platform, F-star is the only biotechnology company able to create bispecific antibodies where the second binding site is in the constant Fc region of an antibody. The strength of the technology and programmes has been leveraged through partnerships with leading biopharmaceutical companies including AbbVie, Bristol Myers Squibb (BMS), Merck Serono, Boehringer Ingelheim and Denali Therapeutics. F-star has currently one programme in the clinic with a second immuno-oncology programme heading toward IND. The company has built a comprehensive IP estate around its technology and product pipeline, with over 50 patent applications filed and over 25 granted patents.

F-star’s management team has a well-established track record in building successful biotech companies, and developing biologics. The team is advised by a world-leading scientific advisory board and a highly experienced board of directors. F-star has raised close to $100M in non-dilutive capital and revenues. The company currently employs over 70 people at its research site in Cambridge, UK.
http://www.f-star.com

Disclaimer
The statements in this press release that relate to future plans, events or performance are forward-looking statements that involve risks and uncertainties, including risks associated with uncertainties related to contract cancellations, developing risks, competitive factors, uncertainties pertaining to customer orders, demand for products and services, development of markets for the Company's products and services. Readers are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof. The Company undertakes no obligation to release publicly the result of any revisions to these forward-looking statements that may be made to reflect events or circumstances after the date hereof or to reflect the occurrence of unanticipated events.

All product and service names mentioned are the trademarks of their respective companies.

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