New Italian Case Study Showcases Benefits of Whole Exome Sequencing for Analyzing Mesothelioma Tumor Origins, According to Surviving Mesothelioma

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Doctors say a mesothelioma patient with three types of lung cancer gave them an opportunity to examine his tumor origins using a specific kind of genetic test.

Mesothelioma Gene Therapy

Genetics and Mesothelioma

Gene therapy is one of the most promising new approaches to treating intractable cancers like malignant mesothelioma...

A new report funded by the italian Health Ministry highlights the potential benefits of whole exome sequencing in understanding the genetic origins of pleural mesothelioma and other cancers and using it to help plan treatment. Surviving Mesothelioma has just posted a new article on the case study. Click here to read it now.

Whole exome sequencing (WES) is the process of sequencing all of an individual’s protein-coding genes. The exome makes up about one percent of a person’s total genome.

“Overall, whole exome sequencing did not disclose any somatic genetic variant shared across the 3 tumors, suggesting their clonal independency,” writes lead author Irene Vanni, MS, of the National Institute for Cancer Research in Genova.

The case study, published in the journal Medicine, suggests that whole exome sequencing may help doctors create targeted gene therapies to treat pleural mesothelioma.

“Gene therapy is one of the most promising new approaches to treating intractable cancers like malignant mesothelioma and genomic sequencing, including whole exome sequencing, is the technology that makes it possible,” says Alex Strauss, Managing Editor of Surviving Mesothelioma.

To learn more about whole exome sequencing and its potential role in mesothelioma therapy, see Exome Sequencing Helps Reveal Origins of Mesothelioma Tumor, now available on the Surviving Mesothelioma website.

Vanni, I, et al, “Whole exome sequencing of independent lung adenocarcinoma, lung squamous cell carcinoma, and malignant peritoneal mesothelioma: A case report”, November 2016, Medicine, e5447,

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Cancer Monthy
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