We detected mild toxicity, long lasting results, and...a clear correlation between PD-L1 expression and response.
Raleigh, NC (PRWEB) December 19, 2016
A paper presented at the recent World Lung Cancer Conference in Vienna, Austria suggests that nivolumab, a PD-1 blocker, may offer an alternative treatment strategy for mesothelioma patients previously treated with chemotherapy. Surviving Mesothelioma has just posted an article on the new report. Click here to read it now.
The Amsterdam-based scientists treated 38 malignant pleural mesothelioma patients with 3 mg/kg of nivolumab for two weeks.
“Nivolumab in second or later lines in recurrent malignant pleural mesothelioma met the primary endpoint,” study author Paul Baas, MD, PhD, said in a statement. “We detected mild toxicity, long lasting results, and we observed a clear correlation between PD-L1 expression and response.”
PD-L1 is a cell surface protein believed to be expressed in as many as 40 percent of mesothelioma tumors.
“Immunotherapy is widely believed to be one of the most promising treatment approaches for intractable cancers like mesothelioma,” says Alex Strauss, Managing Editor for Surviving Mesothelioma. “This study gives us another drug, along with pembrolizumab (Keytruda) and avelumab, to follow as it is further tested.”
To read more details of the nivolumab study and learn about other possible new mesothelioma immunotherapy drugs, see Immunotherapy Drug May Be New Option for Recurrent Mesothelioma, new available on the Surviving Mesothelioma website.
“Nivolumab Shows Promise in Treating Malignant Pleural Mesothelioma”, International Association for the Study of Lung Cancer, News Release, December 7, 2016, http://wclc2016.iaslc.org/wp-content/uploads/2016/12/Netherlands-Baas-Release.pdf
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