By targeting these tumour-derived vessels, we might be able to improve our therapeutic approaches.
Raleigh, NC (PRWEB) December 20, 2016
Australian scientists say the aggressive growth of mesothelioma tumors may be due to their ability to form their own blood vessel-like structures. Surviving Mesothelioma has just posted an article on the new study. Click here to read it now.
Doctors at Flinders University recently found that mesothelioma cells cultured either alone or with human endothelial cells exhibit vascular mimicry, or the ability to form new blood vessels independent of the body’s own angiogenic response.
Writing in the journal Pathology, the team reports that this process not only helps explain the cancer’s fast growth but could also lead to new and better mesothelioma treatments.
“By targeting these tumour-derived vessels, we might be able to improve our therapeutic approaches, while also reducing some of the worst side-effects by switching our focus to inhibiting both vascular mimicry alongside conventional vessel growth,” says study author and Flinders Associate Professor Sonja Klebe.
“This study is exciting because it points to an entirely new way to try to attack mesothelioma,” says Alex Strauss, Managing Editor for Surviving Mesothelioma. “Since all tissues need vasculature to grow, it makes sense to imagine that undermining this process may help undermine mesothelioma tumor growth.”
For a more indepth understanding of these new mesothelioma research findings, see Mesothelioma Tumor Growth Discovery May Open Door to Novel Treatments, now available on the Surviving Mesothelioma website.
Pulford, Emily, “Vasculogenic mimicry in malignant mesothelioma: an experimental and immunohistochemical analysis”, December 2016, Pathology, pp. 650-659, https://www.ncbi.nlm.nih.gov/pubmed/27956272
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