Boston Team Says Nanoprobes Can Light the Way for Mesothelioma Tumor Removal, According to Surviving Mesothelioma

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Using nanoparticles to deliver a fluorescent dye may improve mesothelioma survival by making peritoneal tumors easier to remove.

Nanoprobes May Improve Mesothelioma Survival

Better Visualization for Mesothelioma Tumors

...any technology that improves visualization during surgery also has the potential to improve mesothelioma survival.

A newly published study out of Boston suggests that nanoprobes loaded with fluorescent rhodamine might help surgeons see and remove even the tiniest peritoneal mesothelioma tumors. Surviving Mesothelioma has just posted an article on the study. Click here to read the details.

Researchers with Boston University and Brigham and Women’s Hospital delivered the fluorescent nanoparticles directly into the peritoneal cavity of rats, where cancers like peritoneal mesothelioma grow.

“The covalent incorporation of rhodamine into ~30 nm eNPs increases the fluorescent signal compared to free rhodamine thereby affording a brighter and more effective probe than would be achieved by a single rhodamine molecule,” writes Aaron Colby, a bioengineer at Boston University.

The study, published in the American Chemical Society’s Nano journal, found that the expansile nanoparticles that were used to deliver the fluorescent material were 95 percent accurate at seeking out and exposing peritoneal mesothelioma and other kinds of peritoneal tumors.

“Given that completeness of cytoreductive surgery has a direct bearing on mesothelioma prognosis, it stands to reason that any technology that improves visualization during surgery also has the potential to improve mesothelioma survival,” says Alex Strauss, Surviving Mesothelioma’s Managing Editor.

To read more about how fluorescent nanoprobes may impact peritoneal mesothelioma surgery, see Fluorescent Nanoprobes Improve Visualization During Mesothelioma Surgery, now available on the Surviving Mesothelioma website.

Colby, Aaron, et al, “Highly Specific and Sensitive Fluorescent Nanoprobes for image-Guided Resection of Sub-Millimeter Peritoneal Tumors”, January 18, 2017, ACS Nano, Epub ahead of print, http://pubs.acs.org/doi/abs/10.1021/acsnano.6b06777

For nearly ten years, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Michael Ellis
Cancer Monthy
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