New Trial Finds VEGF-Inhibitor May Safely Boost Mesothelioma Chemotherapy, According to Surviving Mesothelioma

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Researchers say cediranib has “tolerable toxicity” and “promising efficacy” in the treatment of malignant mesothelioma.

Cediranib in Mesothelioma Chemotherapy

VEGF-Inhibitor in Mesothelioma Treatment

Cediranib combined with cisplatin-pemetrexed has a reasonable toxicity profile and preliminary promising efficacy.

A new clinical trial of the VEGF-inhibitor cediranib suggests that, at the right dose, the drug might safely be used to improve the effectiveness of standard chemotherapy for pleural mesothelioma. Surviving Mesothelioma has published a new article on the trial. Click here to read it now.

For the Phase I trial, doctors at several US cancer centers helped test a mesothelioma treatment combination including the oral cancer drug cediranib the the standard mesothelioma chemotherapy drugs pemetrexed (Alimta) and cisplatin.

“Cediranib combined with cisplatin-pemetrexed has a reasonable toxicity profile and preliminary promising efficacy,” writes oncologist Anne Tsao, MD, of MD Anderson Cancer Center in Texas.

The study, published in the Journal of Thoracic Oncology, determined that 20 milligrams of cediranib, taken during each chemotherapy cycle for six cycles, produced a disease control rate of 90 percent and a median overall survival of 16.2 months.

“Although previous studies of cediranib have produced some severe side effects, this study of the drug at a smaller dose suggests that it may still have a role to play in mesothelioma treatment,” says Alex Strauss, Managing Editor for Surviving Mesothelioma.

For the complete details of the new cediranib study, as well as background on the drug, see Cediranib May be Safe Supplement to Mesothelioma Treatment, now available on the Surviving Mesothelioma website.

Tsao, AS, et al, “Phase I Trial of Cediranib in combination with cisplatin and pemetrexed in chemo naive patients with unresectable malignant pleural mesothelioma (SWOG S0905)”, June 6, 2017, Journal of Thoracic Oncology, Epub ahead of print,

For more than a decade, Surviving Mesothelioma has brought readers the most important and ground-breaking news on the causes, diagnosis and treatment of mesothelioma. All Surviving Mesothelioma news is gathered and reported directly from the peer-reviewed medical literature. Written for patients and their loved ones, Surviving Mesothelioma news helps families make more informed decisions.

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Michael Ellis
Cancer Monthy
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