Thermo Fisher Scientific Highlights Findings that Indicate Cancer Cells Send Signals Boosting Survival and Drug Resistance in Other Cancer Cells

Share Article

LabRoots will host the webinar November 14, where participants will learn how endoplasmic reticulum stress in cancer cells may facilitate immune dysregulation and chemoresistance in vivo.

Jeffrey James Rodvold, PhD Postdoctoral Researcher, UCSD

Successful tumor outgrowth requires the coordination of a variety of cell intrinsic and cell extrinsic signaling events. These events include those establishing a tumor microenvironment (TME) that both enables tumor cell survival and disables anti-tumor immunity.

Recent reports demonstrate that these events require molecules produced by resident tumor cells. Tumor-borne signals within the tumor microenvironment propagate tumor cell fitness and immune hijacking. The endoplasmic reticulum (ER) stress is an adaptive response to a variety of TME insults, including hypoxia and nutrient deprivation, raising the possibility that ER stress could serve as a potential source of tumor cell fitness and immune dysregulation.

Through this webinar, attendees will gain a better understanding of how to design an in vitro system to model phenomenon within the tumor microenvironment. They will learn from case studies and study results that revealed that the CM of cancer cells undergoing ER stress transmits ER stress to recipient cells. When implanted into immune competent hosts, ER stress experienced cancer cells grew at markedly faster rates than inexperienced ones. These findings support the existence of a novel mechanism used by tumor cells to restrain anti-tumor immunity while enhancing cellular fitness with the TME.

The team at Thermo Fisher Scientific has arranged for Dr. Jeffrey James Rodvold, a postdoctoral Researcher at the University of California, San Diego, to be the speaker for this event.

Currently a postdoctoral researcher, Rodvold completed his doctorate in biomedical sciences at the University of California, San Diego, where his research focused on the unfolded protein response (UPR) within the tumor microenvironment. His research involved elucidating how the tumor microenvironment becomes dysregulated within both the cancer cell and immune infiltrate compartments through the production of signaling molecules cancers cells producing during the UPR.

This webinar will be hosted on LabRoots.com November 14, 2017, beginning at 10:00 a.m. PST, 1:00 p.m. EST. to read more on this event, learn about the continuing education credits that will be offered, or to register for free, click here.

About Thermo Fisher Scientific
Thermo Fisher Scientific Inc. is the world leader in serving science, with revenues of $18 billion and more than 55,000 employees globally. Our mission is to enable our customers to make the world healthier, cleaner and safer. We help our customers accelerate life sciences research, solve complex analytical challenges, improve patient diagnostics and increase laboratory productivity. Through our premier brands – Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific and Unity Lab Services – we offer an unmatched combination of innovative technologies, purchasing convenience and comprehensive support. For more information, please visit http://www.thermofisher.com.

About LabRoots
LabRoots is the leading scientific social networking website, which provides daily scientific trending news, as well as produces educational virtual events and webinars, on the latest discoveries and advancements in science. Contributing to the advancement of science through content sharing capabilities, LabRoots is a powerful advocate in amplifying global networks and communities. Founded in 2008, LabRoots emphasizes digital innovation in scientific collaboration and learning, and is a primary source for current scientific news, webinars, virtual conferences, and more. LabRoots has grown into the world’s largest series of virtual events within the Life Sciences and Clinical Diagnostics community.

Share article on social media or email:

View article via:

Pdf Print

Contact Author

Karen Sorenson
LabRoots, Inc.
+1 (619) 861-0590
Email >
Visit website